Senior/Principal Scientist, Protein-Biologic Discovery

Oxford BioTherapeutics•San Jose, CA

About The Position

Working independently and in a matrix, this role will lead the development of antigen antibodies against novel targets discovered by Oxford BioTherapeutics, headquartered in the UK. They will be involved in multiple aspects of the production of recombinant proteins, monoclonal antibodies, multi-specific scaffolds and novel protein modalities to enable all aspects of early discovery and validation research.

Requirements

PhD. in biological sciences or related fields with 5+ years of post-Ph.D., or MS with 10+ years of experience in biopharma industry or closely related scientific discipline, preferably in a fast-paced startup environment.
Experience in molecular biology or/and biochemistry, including gene manipulation, subcloning, expression vector modifications, and protein expressions in HEK & CHO cell systems
Extensive practical experience in developing and optimizing recombinant proteins, bi- and multi-specific antibody formats, and antibody developability across multiple parameters is preferred.
Advanced expertise in human protein and antibody purification techniques, including affinity chromatography, ion exchange chromatography (HIC), ion exchange chromatography (IEX), and size exclusion chromatography (SEC). Proficiency in operating and troubleshooting modern chromatography hardware and software, such as Cytiva AKTA systems and Agilent HPLC and UPLC
Antibody drug discovery experience for immune oncology in biopharmaceutical industry is a plus.
Ability to independently lead project strategy, plan, and execution on stringent timelines with quality to meet project goals is plus
Knowledge of the biologics drug discovery process and representation of the protein science function at project team meetings.
Compliance with data management, laboratory notebook policy, and laboratory safety are plus

Responsibilities

Serve as a key contributor to the discovery and development of antibody therapeutics for oncology and immune oncology for novel targets.
Design and implement recombinant protein and bi- and multi-specific antibody discovery plans (immunogen design, assay development, screening, and functional characterization methods) and oversee the executions.
Support biologic discovery through different platforms of protein and antibody discoveries.
Oversee various target projects to execute protein production and antibody discovery/optimization in various platforms
Generate target over-expressing cell lines for antibody discovery work
Develop strategies to express, purify, and analyze proteins for novel tumor targets expressed in mammalian cells
Extensive experience in human protein and antibody purifications using a variety of chromatographic techniques with hands-on experience using and maintaining AKTA FPLC and Agilent HPLC & UPLC.
Characterization of antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope binning/mapping, and functional assays.
Analyze data, interpret results, identify problems, and develop trouble-shooting plans
Participate in the transfer of processes, technology, and assays to/from internal and external collaborators and outside vendors