Senior Principal Scientist – Process Chemist

Eli Lilly and Company • Indianapolis, IN

1d • $65,250 - $169,400 • Onsite

About The Position

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Position Overview: Reporting to the Advisor – Chemist, the Senior Principal Scientist – Chemist will be responsible for supporting the advancement of radiopharmaceutical precursor programs from R&D through early phase clinical stages. The selected candidate will have deep technical expertise in organic synthesis, purification, and characterization techniques to support the development and manufacture of phase-appropriate precursors and related standards. The selected candidate will be comfortable working both independently as well as in collaboration with other departments and external partners to ensure successful development of novel precursor candidates in the RLT pipeline. This position will be within the Precursor team which is part of the Early Phase CMC group.

Requirements

• Master's degree in organic chemistry, medicinal chemistry, organometallic chemistry or related field
• 2+ years of hands-on experience with all aspects of modern synthetic chemistry including designing and executing multi-step syntheses, purification techniques (e.g., chromatography, crystallization), and characterization techniques including HPLC, NMR, MS, etc.
• Demonstrated ability to work effectively in multi-disciplinary team settings and manage relationships with external partners and vendors
• Strong oral and written communication skills with ability to articulate complex scientific concepts clearly
• Strong scientific, analytical, and project management skills
• Proficiency with Microsoft 365 (Excel, Word, PowerPoint)
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Nice To Haves

• PhD in organic chemistry, medicinal chemistry, organometallic chemistry or related field, post-doc experience
• Experience designing and working with metal chelators and radioligand chemistry is considered an asset.
• Experience working in a pharmaceutical GMP manufacturing environment with functional knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines is strongly preferred
• Ability to work effectively both independently and as part of a collaborative team.
• Excellent written and oral communication skills.
• Ability to execute with high attention to detail, strong organizational skills, and extreme sense of urgency.

Responsibilities

• Independently perform complex and diverse organic syntheses, purifications, and characterizations to provide radioligand precursors and related standards.
• Understand the physical and chemical properties of products, raw materials, intermediates, and reagents, with the ability to select appropriate reaction conditions with reference to literature.
• Design and plan expedient synthetic routes based on literature precedent.
• Conduct and interpret a wide variety of modern chemical analyses (e.g., NMR, HPLC, MS).
• Analyze technical data and documents, provide recommendations and planning for subsequent experiments.
• Support synthesis scale-up efforts and other technology transfer activities.
• Accurately record experiments and related data in accordance with GxP requirements
• Maintain a safe and functional laboratory environment including but not limited to equipment maintenance, chemical inventory, and ordering and receiving chemicals and consumables.
• Ensure adherence to local Environmental, Health and Safety (EH&S) regulations, company policies, standard laboratory safety practices, and any other quality or regulatory requirements.
• Provide verbal and written reports and presentations as required in a clear and concise manner.
• In collaboration with managers and cross-functional teams, develop timelines and deliverables to accomplish project goals.
• Multi-task and prioritize project deliverables in a fast-paced environment.

Benefits

• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
• In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

What This Job Offers

• Job Type: Full-time
• Career Level: Senior