Senior Principal Scientist, ADC Oncology Discovery Biology

Bristol Myers Squibb • VA

114d • $181,930 - $220,451

About The Position

Join our world-class ADC Discovery team and play a pivotal role in advancing next-generation oncology therapeutics. As a Senior Principal Scientist, you will lead innovative projects from concept to clinic, leveraging proprietary technologies and collaborating with top experts in the field. You’ll have the autonomy to shape scientific strategy, mentor rising talent, and make a tangible impact on patient outcomes. Our team thrives on creativity, rigorous science, and a shared commitment to transforming cancer care. We are seeking a creative scientist leader with experience leading antibody-drug conjugate (ADC) drug discovery teams from target concept to IND filing. The successful candidate will contribute to the next wave of ADC innovation as a member of the Discovery Biology ADC Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA.

Requirements

• Bachelor’s Degree with 10+ years of academic and/or industry experience, or a Master’s Degree with 8+ years of experience, or a Ph.D. or equivalent advanced degree in the Life Sciences with 6+ years of experience.
• 2+ years of leadership experience.
• Experience discovering novel linker-payloads beyond traditional cytotoxic linkers.
• Experience leading and collaborating across matrixed ADC discovery programs from concept to IND.
• Strong problem-solving skills and understanding of complex scientific principles.

Nice To Haves

• Ph.D. or equivalent advanced degree in the Life Sciences.
• Experience profiling and developing complex biologics (i.e. bispecifics, biparatopics, masked antibodies).
• Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes.
• Experience contributing to an IND.
• Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity.

Responsibilities

• Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation.
• Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates.
• Collaborate with functional area leads e.g. pharmacology, DMPK, bioinformatics to drive programs forward, including helping to define program priorities and risks.
• Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships.
• Present complex concepts to a range of audiences including governance and full team project meetings.
• Utilize excellent communication and interpersonal skills.

Benefits

• Medical, pharmacy, dental and vision care.
• Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
• Financial well-being resources and a 401(K).
• Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance.
• Work-life programs including paid national holidays, up to 120 hours of paid vacation, and sick time off.
• Parental, caregiver, bereavement, and military leave.
• Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits.
• Tuition reimbursement and a recognition program.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees