Senior/Principal Business Manager- Translational Medicine

Genentech • South San Francisco, CA

111d • $144,000 - $267,400

About The Position

The Senior/Principal Business Manager will serve as a strategic advisor and thought partner to senior leadership within the gRED Translational Medicine organization. This individual will play a critical role in driving cross-functional alignment, enabling business planning and operational excellence, and ensuring the successful execution of strategic priorities. The role requires strong business acumen, systems thinking, and the ability to influence and partner across multiple levels and functions. The Business Manager also enables leadership team effectiveness by shaping agendas, connecting strategic dots, and anticipating organizational needs. With a strong grasp of the enterprise landscape, the Senior Business Manager proactively connects strategic priorities to execution, facilitates sound decision-making, and identifies opportunities to strengthen how the organization operates, collaborates, and delivers impact.

Requirements

• A skilled communicator with strong written, verbal, and presentation abilities—able to synthesize and convey complex information clearly and effectively to diverse audiences.
• Highly organized, with exceptional program and project management capabilities.
• Trusted relationship builder who fosters collaboration, psychological safety, and transparency across teams and leadership levels.
• Agile and resourceful in navigating ambiguity and shifting priorities, with a proactive and solutions-oriented mindset.
• Adept at identifying process improvements and delivering business impact through operational excellence.
• Demonstrated experience in business management disciplines such as: Strategic planning, Organizational development, Project and portfolio management, Business process improvement, Change management, Internal communications and engagement.
• Proven success leading cross-functional initiatives in complex matrixed environments.
• Background in clinical development, drug development, or translational research is preferred.
• Strong understanding of enterprise functions, organizational dynamics, and business operations.
• Formal degree preferred; equivalent training and experience will be considered.

Nice To Haves

• Additional training or certification (e.g., PMP, Six Sigma, Design Thinking, Agile) is a plus.

Responsibilities

• Serving as a strategic thought partner to senior functional leaders (Director and Vice President level), providing insights and driving aligned decision-making in support of organizational goals.
• Leading short- and long-term business planning efforts, including annual planning cycles, resource allocation, budget forecasting, and functional goal setting.
• Driving leadership team operating rhythm, ensuring effective prioritization, focus, and delivery on strategic objectives.
• Anticipating emerging needs, risks, and opportunities across the organization and proactively frames options for leadership consideration.
• Facilitating effective leadership and project team operations—designing and executing agendas, preparing briefing materials, and ensuring clarity of decisions, follow-ups, and outcomes.
• Connecting the dots across initiatives and stakeholders, identifying interdependencies and proactively addressing risks and opportunities.
• Synthesizing data and perspectives to support informed decision-making, including preparing pre-reads, strategic recommendations, and decision frameworks for leadership discussions.
• Driving planning and execution of strategic initiatives and change efforts that support the function's success and alignment with gRED and enterprise priorities.
• Advising on and contributes to solutions for complex challenges, offering structure, process, and creative thinking to move initiatives forward.
• Supporting key people and culture activities—such as functional offsites, recognition programs, and engagement initiatives—helping to foster a high-performance, inclusive, and purpose-driven environment.
• Acting as a connector across teams, promoting collaboration, shared accountability, and alignment toward common goals.
• Supporting communication strategies to ensure transparency, clarity, and engagement across stakeholders and organizational levels.
• Bringing a strong enterprise mindset, continuously linking functional goals to broader strategic context and organizational objectives.

Benefits

• Discretionary annual bonus may be available based on individual and Company performance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree