Senior Medical Director, Oncology Clinical Development (Office Based - Cambridge, MA)

Zai Lab (US) LLC • Cambridge, MA

101d • $299,000 - $332,000

About The Position

The Senior Medical Director will lead late-stage clinical development programs in Oncology, including pivotal Phase III trials and registration studies. Responsibilities include independently contributing to and executing on the clinical strategy, serving as Medical Monitor, supporting regulatory submissions and commercialization efforts, and collaborating and leading cross-functional teams. The role plays a key part in scientific oversight to ensure successful execution and advancement of oncology assets and representing Zai Lab externally. This role is based in our Cambridge, MA office.

Requirements

• MD with board certification in Oncology, Hematology-Oncology, or a related specialty.
• Five years of clinical development experience, with a focus on late-stage oncology trials.
• Ability to work across several time zones and travel up to 30%.

Nice To Haves

• Proven track record as a Medical Monitor for pivotal trials and successful regulatory submissions.
• Deep understanding of oncology drug development, clinical endpoints, and regulatory pathways.
• Proven ability to lead cross-functional teams and manage complex clinical programs.
• Clinical practice experience or experience as an investigator is a plus.
• Excellent leadership, strategic thinking, and communication skills.
• Strong collaboration skills to effectively interact with internal and external stakeholders.
• Demonstrated commitment to high personal values and ethical standards.

Responsibilities

• Provide medical leadership for the design and execution of late-stage clinical trials, including pivotal and confirmatory studies.
• Serve as Medical Monitor for Phase III and registration trials, ensuring patient safety, protocol compliance, and timely medical oversight.
• Contribute expert medical and scientific leadership to clinical development strategies, regulatory submissions, and lifecycle planning.
• Work closely with regulatory affairs, clinical operations, pharmacovigilance, biostatistics, medical affairs, and commercial teams to align clinical and business objectives.
• Represent Zai Lab in interactions with investigators, key opinion leaders, regulatory authorities, and external collaborators.
• Analyze clinical trial data and real-world evidence to identify trends, assess efficacy and safety signals, and support data-driven decision-making.
• Develop strategies for label expansion, post-marketing commitments, and long-term product differentiation.
• Lead the preparation of regulatory documents, participate in health authority interactions globally, and contribute to risk management planning and mitigation strategies throughout the development lifecycle.
• Provide clinical expertise to support licensing opportunities, partnerships, and due diligence activities.
• Build strong relationships, challenge ideas constructively, and drive impactful decision-making based on scientific evidence.
• Maintain up-to-date knowledge of oncology trends, the competitive landscape, and regulatory changes to inform clinical strategy.

Benefits

• Sign-on bonus
• Restricted stock units
• Discretionary awards
• Full range of medical benefits
• Financial benefits including 401(k) eligibility
• Various paid time off benefits, such as vacation, sick time, and parental leave

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: No Education Listed
• Number of Employees: 1,001-5,000 employees