Senior Medical Director, Kidney Disease, Early Clinical Development CVRM
About The Position
T he Senior Medical Director will be focused on Kidney Disease and related conditions that impact kidney function . In this role, you will have the opportunity to work at the forefront of early clinical and translational research within CVRM. In a multidisciplinary environment, you will play a key role in progressing a rich and diverse pipeline of both small and large molecules in numerous active clinical programs. Who W e A re In the Cardiovascular, Renal & Metabolism (CVRM) Translational Medicine & Clinical Development (TSCD) department , we are investigating the underlying factors contributing to CVRM disease progression using advanced scientific methodologies and data-driven drug discovery. In this context, we are evaluating a wide range of different drug modalities from our rich CVRM portfolio of compounds across kidney disease patient populations. TSCD is where science meets clinical drug development with a focus upon deliver ing innovative , early phase clinical studies and accelerat ing human target validation while collaborating closely with our late phase clinical development and regulatory colleagues who guide our pivotal phase 3 clinical studies . What Y ou Wi ll D o You will be responsible for managing and lead ing to early phase I-II global clinical trials and related clinical research projects for compounds that are targeting kidney disease , as well as serving as an expert on the design, conduct, monitoring, data interpretation, and reporting of these studies. Additionally, you will work on cross-functional teams within our TSCD group and across the broader global CVRM organization that are framing our strategies and development plans for compounds that are targeting cardiovascular diseases such as H eart F ailure, as well as major metabolic disorders , such as Type 2 Diabetes, Obesity, and Metabolic Dysfunction-Associated Steatohepatitis , given that these disorders intersect with chronic kidney disease and influence disease progression.
Requirements
- MD , MBBS or MD/PhD with established clinical or research expertise in in the treatment of kidney diseases .
- Minimum of 5 years of clinical research in academia and/or the pharmaceutical / biotechnology industry .
- Experience designing, executing , monitoring , interpreting , and overseeing safety in early clinical and translational trials preferred.
- Strong command of biomarkers , surrogate endpoints, and biostatistics , supported by a robust publication record.
- Well developed interpersonal skills , effective teamwork , and the ability to engage stakeholders effectively across functions , geographies , and disciplines .
Responsibilities
- Lead early Phase I–II global trials in kidney disease : clinical strategy , protocol design, study conduct , monitoring , data interpretation, and reporting , ensuring scientific integrity , patient safety, and regulatory compliance .
- Provide clinical leadership to cross- functional teams; integrate preclinical insights ( target selection , pharmacology , in vivo /in vitro data) into early clinical plans and seamless transitions to late phase development .
- Contribute to regulatory interactions and documentation ( e.g ., CTAs , INDs, safety updates , annual reports ).
- Advance the development and validation of non clinical and surrogate endpoints ( including imaging and biomarkers ).
- Represent TSCD internally and externally through presentations, publications , and scientific forums; engage with external experts and translate insights into strategy and study design.
- Help evolve trial operations and site engagement to improve speed, quality , and inclusivity in early studies.
- Collaborate across CVRM on programs in heart failure , type 2 diabetes, obesity , and metabolic dysfunction-associated steatohepatitis , given their intersection with kidney disease .
Benefits
- qualified retirement program [401(k) plan]
- paid vacation and holidays
- paid leaves
- health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans
- short-term incentive bonus opportunity
- eligibility to participate in our equity-based long-term incentive program
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
