Senior Medical Director, Global Rare (Medical Affairs)

Alnylam Pharmaceuticals•Cambridge, MA

2d•$284,000 - $384,200•Hybrid

About The Position

The Sr. Medical Director, Global Rare, reporting to the VP, Global Rare Medical Lead, is responsible for providing global strategic and scientific support for the Rare Disease franchise. This role focuses exclusively on currently marketed products within Alnylam’s Rare Disease portfolio. The individual will lead key initiatives of the global medical team, including evidence generation, scientific communication, and stakeholder engagement, all centered on supporting and optimizing the use of marketed therapies in this space. The successful candidate will serve as the primary point of contact for country medical teams globally and will be liaising with counterparts in Regulatory, Safety, Program Leadership, MAC (Global and Regional) and other relevant expertise areas within medical (e.g., VESt/Med Research, medcom/pub, med info, and patient advocacy).

Requirements

PhD in life sciences or PharmD required, MD strongly preferred
Experience in leading Medical Affairs activities in North America and European countries
Demonstrated high-level professional knowledge and skills in the areas of medical affairs and R&D in the pharmaceutical or biotech industry
Experience leading teams/programs in a matrix environment highly preferred
Demonstrate experience in rare or genetic diseases highly preferred
Knowledge of the biopharmaceutical industry and evidence generation with an understanding of key regulatory bodies
High degree of professionalism, maturity, and confidentiality
Strong written and verbal communication skills as well as strong leadership and interpersonal skills
Demonstrated reputation as a well-respected, dynamic team leader, player and coach
Capable of managing shifting priorities in a rapidly changing environment
Ability to deliver on company global program goals and objectives as they pertain to medical affairs
Ability to affect positive organizational change at the company and team levels

Responsibilities

Serve as the primary point of contact for global medical affairs activities and act as escalation point for complex regional medical issues.
Provide strategic and scientific input to the Rare Disease franchise within the global medical matrix team framework; ensure alignment of global medical strategy with program strategy. Represent medical affairs at Program Leadership Team and Global MAC.
Accountable for strategic leadership and oversight of all medical affairs activities in partnership with VESt, Medical Communications and Training, PAE, and Medical Operations.
Ensure compliance with global and local regulations, including oversight of pharmacovigilance reporting obligations in collaboration with Safety teams.
Collaborate with Clinical Development and VESt to provide medical affairs input into pivotal study design; work closely with Preclinical, Regulatory, Clinical Operations, Biometrics, and Commercial to integrate product development and lifecycle plans.
Define and prioritize therapeutic area-specific evidence gaps; develop and implement evidence generation strategies (e.g., natural history studies, phase 4 trials, registries) to address stakeholder needs.
Provide medical oversight for observational studies, comparative effectiveness research, chart reviews, registries, and other evidence generation projects.
Partner with Medical Communications to ensure timely dissemination of scientific data through publications and congress activities.
Collaborate with Medical Training to design and deliver high-quality scientific and skill-based training for global and regional medical teams.
Review regional commercial materials (CRB) and medical materials (MRB) for scientific accuracy and consistency.
Develop and maintain relationships with global KOLs, policy makers, and payer organizations to support education and access.
Represent the company at external scientific forums, advisory boards, and rare disease consortia.
Work closely with Global Marketing and European Regional Marketing to define stakeholder engagement strategies and drive global KOL engagement activities.

Benefits

comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match
Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks
We also offer generous family resources and leave

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