Senior Medical Director Clinical Development, Amyloidosis and Rare Cardiology

AstraZeneca • Boston, MA

7d • Hybrid

About The Position

The Senior Medical Director Clinical Development will lead the clinical team for a high-visibility program and report to the Global Clinical Head. This is an excellent opportunity for an experienced and motivated drug developer to advance an innovative, late-stage ATTR amyloidosis study. The SD will provide medical leadership across all stages of clinical development, from IND/CTA and First-in-Human through Proof-of-Concept and End-of-Phase 2 and beyond. Acting as a key medical expert on the study team(s), the SD may also serve as medical monitor as needed. In this role, the SD will work cross-functionally and mentor Physicians, Clinical Directors, and Clinical Development Scientists. The position may include direct and indirect managerial responsibilities for team members across the Clinical Development organization. The SD will also contribute to the development of regulatory, therapeutic area, and functional strategies. This position offers the opportunity to collaborate closely with enterprise-level, cross-functional teams, including AstraZeneca Business Units, CVRM, and strategic development partners. The ideal candidate will thrive in a fast-paced, proactive, and collaborative culture—demonstrating strong communication skills, scientific leadership, and the ability to drive impact across both internal and external teams.

Requirements

• MD with specialty training in Cardiology or Internal Medicine.
• 7+ years of experience in clinical development; clinical research, global regulatory, and product development expertise
• Has prepared documents and attended regulatory meetings with FDA and other regulatory agencies.
• Experience designing and executing multinational clinical trials required
• Demonstrated ability to lead cross-functional teams to define clinical strategy and clinical study design.
• Experience supporting business development activities.
• Ability to learn rapidly, think critically, and operate effectively in a fast-paced environment.

Nice To Haves

• Board Certification.
• Experience in ATTR amyloidosis
• Preferred: Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data.
• PhD in related discipline desirable.
• Experience with BLA/MAA submissions.
• Demonstrated experience as a clinical trialist with a strong external network, including relationships with key investigators, sites, and patient partners.
• Experience operating at the clinical-commercial interface and shaping clinical strategies with commercial insight.
• Broad awareness of the global therapeutic landscape and regulatory environment within rare or cardiometabolic diseases.
• Willingness and ability to travel nationally and internationally.

Responsibilities

• Lead cross-functional clinical program teams to deliver high-quality studies and research strategies, ensuring scientific rigor and optimal benefit–risk management.
• Serve as the clinical authority for assigned programs, overseeing study design, execution, data interpretation, and regulatory deliverables in compliance with GCP.
• Provide strategic medical and scientific input across R&D, translational science, commercial, and business development activities, including due diligence and collaborations.
• Mentor and develop Medical Directors, Clinical Development Scientists, and fellows to build organizational scientific and leadership capability.
• Monitor and interpret evolving scientific, clinical, and competitive intelligence in ATTR amyloidosis to inform program strategy and innovation.
• Represent the program internally and externally through governance presentations, regulatory interactions, scientific publications, and engagement with key opinion leaders.

Benefits

• Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees