Cytokinetics-posted 4 months ago
Senior
Radnor, PA
501-1,000 employees

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility. The Senior Manager, Regulatory Writing is responsible for authoring regulatory documents, including but not limited to clinical study protocols, protocol amendments, clinical study reports (CSRs), clinical summaries, investigator’s brochures (IBs), pediatric documents, and regulatory authority briefing materials and responses. This individual will work independently with minimal oversight and in close collaboration with cross-functional teams to lead the development of these documents. All work must ensure scientific accuracy, alignment with study and submission objectives, compliance with standard operating procedures (SOPs), ICH/GCP and regulatory guidelines, and company goals. The Senior Manager will interpret and summarize complex regulatory data from a variety of sources in a concise, fit-for-purpose manner. This role requires strong attention to detail, critical thinking, and adherence to best writing practices. The Senior Manager will also lead and facilitate cross-functional meetings such as document kickoff meetings, data interpretation meetings, and comment resolution meetings. In addition, the role involves managing multiple complex writing projects, requiring excellent time management, problem-solving, and stakeholder engagement skills. The individual in this role will have demonstrated experience as a lead writer for a range of regulatory documents, including submissions, briefing materials, and responses to health authority questions. The role may also support other departmental Regulatory Writing activities as needed.

  • Write, review, and edit clinical and regulatory documents such as clinical study protocols, CSRs, IBs, clinical summaries, and other documents as required for complex submissions (IND/NDA/BLA/MAA).
  • Provide support for health authority briefing documents, and responses to questions/requests for information, as needed.
  • Serve as the primary point of contact for submission and project teams while acting as the lead author for complex documents while supporting document timelines and content strategy.
  • Oversee additional writing and QC work performed by the vendors.
  • Plan kickoff meetings, define overall timelines and lead authoring and comment resolution for large, complex documents (e.g., CSRs).
  • Arrange and conduct comment resolution/review meetings with cross-functional teams and resolve document content issues independently or collaboratively.
  • Work with cross-functional stakeholder groups, including Clinical Research, Biometrics, Drug Safety, Regulatory, Clinical Pharmacology etc. to set priorities for document preparation.
  • Represent Regulatory Writing on project teams and advise on fit for purpose content and format requirements for various documents.
  • Develop and drive timelines, and communicate writing process and timelines to team members.
  • Provide status/updates of Regulatory Writing deliverables to management.
  • Share and implement Regulatory Writing best practices to ensure efficiency and consistency across product teams.
  • Contribute content to safety documents (e.g., DSURs, RMPs).
  • Serve as a subject matter expert on systems and process initiatives including document management system implementations and updates to document development practices.
  • Comply with established company policies and procedures, and industry and regulatory guidelines.
  • Other duties as assigned.
  • BA/BS in one of the life sciences with a minimum of 8+ years of scientific or medical writing experience at a biotech/pharmaceutical company; or MA/MS/PhD with 5+ years of relevant regulatory/medical writing experience.
  • Deep understanding of regulatory standards and data-driven documentation.
  • Excellent communication skills both orally and in writing.
  • Ability to work both independently and in cross-functional team environments with minimal supervision.
  • Demonstrated ability to lead development of large/complex regulatory and clinical documents including but not limited to CSRs, module 2 summaries, and regulatory authority meeting briefing documents.
  • Ability to engage and disseminate information among appropriate stakeholders for effective document preparation.
  • Strong attention to detail with the ability to effectively write/summarize science-and data-driven content into clear, concise, and complete documents.
  • Skilled in verifying data integrity, identifying errors and inconsistencies across various document types, and addressing them effectively.
  • Ability to work effectively in a fast-paced environment with multiple high-priority projects.
  • Ability to oversee consultants/contractors and serve as a liaison for project purposes.
  • Excellent Project management skills.
  • Knowledge of regulatory guidelines (e.g., ICH) and Good Clinical Practices (GCP).
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