Senior Manager, Program Management and Drug Substance Lead

Vor Bio•Boston, MA

10d•$155,000 - $175,000•Onsite

About The Position

We are seeking a Senior Manager, Program Management & Drug Substance Lead to support execution of drug substance development and manufacturing programs for biologics. This role combines program management with hands-on understanding of CHO-based manufacturing to ensure activities are well-coordinated, risks are proactively managed, and supply aligns with clinical and commercial needs. You will play a key role in advancing programs through late-stage development by working across internal teams and external partners to deliver reliable, scalable drug substance supply.

Requirements

Bachelor’s degree in life sciences, engineering, or related field; advanced degree preferred
6–10+ years of experience in biologics drug substance development, manufacturing, or CMC program management
Experience with CHO cell-based manufacturing systems required
Working knowledge of upstream (cell culture) and downstream (purification) processes
Experience supporting tech transfer, scale-up, and manufacturing execution
Experience working with external manufacturing partners (CDMOs)
Strong program management and data management skills; experience with tools such as Smartsheet preferred
Strong ability to manage timelines, track deliverables, and drive execution in a fast-paced environment.
Working knowledge of biologics drug substance development, including CHO cell culture, upstream and downstream processes.
Ability to work effectively across teams and manage competing priorities.
Strong analytical mindset with the ability to identify risks and support practical solutions.
Clear and organized communicator, able to provide concise updates to stakeholders.

Responsibilities

Drive day-to-day program execution across drug substance activities.
Develop and maintain integrated timelines, track deliverables, risks, and dependencies, and ensure alignment across CMC, Quality, Regulatory, Clinical, and Supply Chain teams.
Support drug substance activities for biologics, including CHO cell line–based processes.
Contribute to process development, tech transfer, scale-up, and manufacturing readiness.
Partner with technical teams to ensure processes are robust, scalable, and aligned with program timelines.
Coordinate activities across CDMOs and external partners.
Track manufacturing progress, ensure deliverables meet expectations, and escalate risks or issues as needed.
Support preparation for manufacturing campaigns and monitor execution.
Partner with Supply Chain to align drug substance manufacturing with clinical and commercial demand.
Support planning activities, including production scheduling, inventory tracking, and risk mitigation for supply continuity.
Identify program and technical risks and support development of mitigation plans.
Work cross-functionally to resolve manufacturing, process, or supply issues in a timely manner.
Coordinate across Quality, Regulatory, Clinical, Commercial, and Finance teams to ensure alignment on priorities, timelines, and deliverables.
Support regulatory documentation and ensure consistency of CMC information.
Maintain program plans, trackers, and dashboards using tools such as Smartsheet.
Ensure timelines, risks, and decisions are accurately captured and communicated through clear updates and reporting.