Senior Manager, Principal Software Engineer, Clinical Pharmacology and Pharmacometrics

Bristol Myers Squibb • Princeton, NJ

1d • $150,110 - $200,088

About The Position

The Principal Software Engineer will lead the design, development, and deployment of innovative software and data platforms supporting Clinical Pharmacology & Pharmacometrics within BMS R&D. This role partners closely with computational scientists and IT teams to enable advanced analytics, modeling, simulation, and workflow optimization, leveraging cloud, HPC, AI/ML, and modern data technologies to accelerate drug development and translational science.

Requirements

• BS/MS/PhD in Computer Science, Software Engineering, or related field; higher degrees preferred.
• 7+ years hands-on experience in software engineering, ideally in life sciences or healthcare domains.
• Proven track record architecting and delivering production-grade software and data platforms (preferably supporting scientific research, modeling or analytics).
• Experience in cross-functional collaboration in matrixed, stakeholder-driven environments.
• Developer with programming skills in Python (primary) and R, integrating with API endpoints in AWS or Google cloud, knowledge of markdown languages such as Quarto/Typst
• Demonstrated success building GenAI applications and agentic workflows, including fine-tuning and deploying LLMs.
• Proven experience working with LLM-based content ingestion, prompt engineering, and automating content generation involving complex tables, images, special characters, headers, footers, and merged columns to produce new reports from diverse source documents.
• Experience working of cloud services (AWS, Azure, GCP), HPC, Kubernetes, and parallel/distributed computing.
• Familiarity with software validation, compliance, and best practices in regulated environments.
• Understand all aspects of software development lifecycle
• Understand various SDLC methodologies (Agile, Scrum, Waterfall etc.)
• Familiarity with MATLAB, WebAPP
• Excellent problem-solving, communication, and stakeholder engagement skills.

Nice To Haves

• knowledge of vector databases and graph RAG would be a plus
• Experience with Posit Workbench/RStudio Server, NAS integration, or similar collaborative scientific platforms.
• Knowledge of QSP, PBPK, PK/PD modeling or pharmaceutical R&D workflows.
• Experience implementing robust access controls, NFS, ACLs, and enterprise authentication.
• Agile and DevOps methodologies, CI/CD, and automation scripting (e.g., Bash, Ansible, CFT, Terraform).

Responsibilities

• Support deployment and operation of AI/ML models, simulation tools, and dashboards for scientific users.
• Lead the integration of HPC, cloud, and Kubernetes-based compute environments; optimize parallelization and resource utilization.
• Collaborate with domain scientists, IT, and other stakeholders to gather requirements and translate scientific workflows into robust technical solutions.
• Drive continuous improvement through automation, system upgrades, and stakeholder feedback.
• Manage platform security, validation, and compliance in coordination with IT and cybersecurity teams.
• Architect, develop, and maintain scalable software systems and data platforms for clinical pharmacology and pharmacometrics use cases.
• Mentor engineers and contribute to best practices (CI/CD, Agile).
• Troubleshoot, monitor, and optimize performance of deployed systems.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
• Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees