Senior Manager, Clinical Site Partner (CSP)

Summit Therapeutics

About The Position

Summit Therapeutics Inc. is a biopharmaceutical oncology company focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. The company values integrity, passion for excellence, purposeful urgency, collaboration, and commitment to people, with employees driving its mission. Summit is involved in multiple global Phase 3 clinical studies in Non-small Cell Lung Cancer (NSCLC) and Colorectal Cancer (CRC) for ivonescimab, an investigational therapy. The company is headquartered in Miami, Florida, with offices in California, New Jersey, the UK, and Ireland. The Senior Manager, Clinical Operations Site Partner (CSP) provides leadership and operational expertise for Phase I–III clinical trials across the US. Reporting to the Associate Director, Clinical Operations Site Partner (US) within the Global Clinical Operations (GCO) group, this role is crucial for operational excellence in trial conduct and site performance. The position serves as the primary Summit operational point of contact for assigned clinical trial sites, accountable for end-to-end operational delivery, driving study start-up efficiency, accelerating site activation and recruitment, and maintaining high standards of performance and quality. The Senior Manager CSP acts as a strategic partner to sites and study teams, aiming to establish Summit as a Sponsor of Choice by providing a concierge-level experience to clinical trial sites.

Requirements

Bachelor’s degree (BA/BS) in a scientific or medical discipline required.
Minimum of 8 years of industry experience in clinical research or related functions.
Extensive late-stage oncology clinical trial experience required.
Proven track record of operational excellence in multi-country clinical trial management.
Strong understanding of drug development processes and regulatory environments in Europe.
Exceptional organizational and planning abilities with demonstrated success in managing complex projects.
Strong analytical and problem-solving skills, with the ability to anticipate challenges and develop pragmatic solutions.
Understand and clearly articulate the development plan and strategic rationale.
Excellent interpersonal, written, and verbal communication skills.
Ability to build effective partnerships with internal stakeholders, investigators, and external partners.
Demonstrated leadership and influencing skills, with the ability to drive accountability and results.
Comfortable working independently in a fast-paced, dynamic, and global environment.
Willingness to travel up to 75% of the time within the US.

Nice To Haves

Advanced degree (MSc, PharmD, PhD) preferred.
Prior experience as a Clinical Research Associate (CRA) and/or Regional/Clinical Operations Manager within a CRO or sponsor organization highly desirable.

Responsibilities

Serve as the main operational contact for assigned clinical trial sites across Europe.
Provide leadership and oversight for all operational aspects of site performance, from feasibility through study closeout.
Recommend sites based on indication, experience, capabilities, and local knowledge.
Support and contribute to feasibility assessments and site selection activities.
Engage investigators early to gather feedback on protocol design, recruitment expectations, and local practices.
Drive efficiency in study start-up and expedite site activation timelines.
Maintain deep knowledge of site capabilities, processes, and requirements.
Expertise in the US Clinical Trial Workflows and state-specific regulations and guidelines.
Act as a facilitator between Summit functions and site teams to ensure seamless communication and coordination.
Participate in site visits, investigator meetings, and study-related interactions as required.
Proactively identify and address obstacles impacting site recruitment and performance.
Track key performance metrics to assess site progress, mitigate potential risks, and implement corrective actions.
Develop and deploy effective strategies to improve site engagement and performance.
Deliver concierge-level support to sites, ensuring an optimal partnership experience.
Contribute to continuous improvement initiatives within Clinical Operations.
Perform all other duties as assigned.