Amazon is looking for a Senior Applied Science Manager to help build the next generation of buying systems. The Optimal Sourcing Systems (OSS) owns the optimization of inventory sourcing and the orchestration of inbound flows from vendors worldwide. We source inventory from thousands of vendors for millions of products globally while orchestrating the inbound flow for billions of units. Our goals are to increase reliable access to supply, improve supply chain-driven vendor experience, and reduce end-to-end supply chain costs, all in service of maximizing Long-Term Free Cash Flow (LTFCF) for Amazon. As an Applied Scientist, you will work with software engineers, product managers, and business teams to understand the business problems and requirements, distill that understanding to crisply define the problem, and design and develop innovative solutions to address them. Our team is highly cross-functional and employs a wide array of scientific tools and techniques to solve key challenges, including optimization, causal inference, and machine learning/deep learning. Some critical research areas in our space include modeling buying decisions under high uncertainty, vendors' behavior and incentives, supply risk and enhancing visibility and reliability of inbound signals.