Senior Infrastructure Engineer II

Ardelyx • Waltham, MA

20d • $149,000 - $182,000

About The Position

Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA® (tenapanor) and XPHOZAH® (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL® (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada. Position Summary: The Senior Infrastructure Engineer II is the most senior individual contributor within Infrastructure Engineering and serves as the technical authority for Ardelyx’s hybrid cloud and on-prem infrastructure platforms. This role combines deep hands-on expertise with architectural ownership and strategic influence to ensure infrastructure systems are scalable, resilient, secure, and aligned with long-term business objectives. The Senior Infrastructure Engineer II owns platform-level architecture, standards, and engineering direction. This individual leads complex initiatives across cloud, identity, networking, virtualization, automation, and observability, mentors senior engineers, and acts as a trusted technical advisor to IT leadership and business stakeholders.

Requirements

• Bachelor’s degree, advanced degree preferred, in Information Technology, Computer Science, Engineering, or related field with 10+ years of progressive infrastructure engineering experience or equivalent experience
• Deep technical expertise across cloud, hybrid, and enterprise infrastructure platforms
• Proven experience owning platform architecture and influencing long-term technical strategy
• Demonstrated leadership on complex, cross-functional infrastructure modernization initiatives
• Strong experience with automation, infrastructure-as-code, and scalable system design patterns
• Ability to translate business and risk requirements into durable technical architecture and roadmaps
• Recognized as a technical authority and mentor across engineering teams
• Proven experience defining and influencing engineering standards, patterns, and best practices across the organization

Nice To Haves

• Advanced or expert-level certifications preferred (Azure Architect, AWS Solutions Architect, VMware, HyperV)

Responsibilities

• Own and lead the full lifecycle of complex, multi-domain infrastructure initiatives from architecture and design through implementation, optimization, and operational readiness
• Define, document, and evolve infrastructure architecture standards and reference designs to ensure scalability, resiliency, security, and cost efficiency
• Drive long-term infrastructure strategy and modernization initiatives, including automation platforms, cloud-native architectures, and zero-trust-aligned designs
• Develop and maintain high-quality architecture artifacts, design documents, and technical roadmaps; clearly articulate tradeoffs and risk to technical and executive audiences
• Design and optimize enterprise-scale compute, storage, virtualization, identity, and cloud platforms for performance, reliability, and scalability
• Own infrastructure resiliency architecture, including backup, disaster recovery, and business continuity design and testing
• Establish and improve observability standards (monitoring, alerting, telemetry) to reduce MTTD and MTTR across platforms
• Serve as the highest-level technical escalation point for critical infrastructure, cloud, identity, and network incidents
• Mentor and guide Senior Infrastructure Engineer I and other engineers through design reviews, technical coaching, and standards enforcement
• Influence capacity planning, automation strategy, and long-term architectural decisions to support sustainable business growth

Benefits

• Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Number of Employees: 251-500 employees