Senior Engineer, Bioengineering Instrumentation Systems

Spear Bio • Woburn, MA

73d

About The Position

Spear Bio, founded in 2021, is a well-funded and rapidly growing biotech start-up headquartered in Woburn, Massachusetts. Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that deliver unparalleled accuracy in measuring low-abundant biomarkers, enabling clinicians and researchers to improve patient outcomes and advance global health. We are seeking a Senior Systems Integration Engineer to contribute to workflow automation and instrumentation integration activities that connect our assays with advanced hardware and software platforms. This role requires a systems-oriented thinker who can work across biology, mechatronics, and software to design, integrate, and refine complex systems. You will collaborate closely with internal teams and external CDMO partners to drive systematic integration, testing, and deployment of end-to-end solutions.

Requirements

• Master’s or Ph.D. in Mechanical/Electrical Engineering, Biomedical Engineering, Bioengineering, or related field.
• 5+ years of experience in systems integration, instrumentation design, or automation engineering specifically in biotech/diagnostics industry required.
• Strong foundation in systems engineering and integration methodologies.
• Hands-on experience with liquid handling systems and other workflow automation platforms (prior FAST and qPCR module integration experience).
• Familiarity with mechatronics, robotics, and thermal/optics subsystems.
• Proficiency in software development for instrument control and automation (Python, C#, or similar).
• Familiarity with data analysis and workflow/pipeline integration tools.
• Exposure to proteomics, molecular biology assays, or related life science applications.
• Experience integrating assay workflows with hardware and software platforms.

Nice To Haves

• Strong problem-solving and troubleshooting skills.
• Excellent communication and collaboration abilities across disciplines.
• Ability to work systematically in fast-paced, collaborative environments.

Responsibilities

• Design, implement, and optimize automated workflow protocols using FAST platforms and other advanced liquid handling systems.
• Develop software tools for instrument control, workflow automation, and integration with data pipelines.
• Define integration schemas for module-to-module system-level integration.
• Break down systems into submodules for testing, troubleshooting, and staged integration.
• Drive system-level validation and performance benchmarking in collaboration with CDMO partners.
• Build versatile tools for workflow scheduling, data acquisition, and pipeline integration.
• Support system data analysis and instrument performance monitoring.
• Partner with assay development scientists to translate proteomics and molecular biology protocols into robust automated workflows.
• Work with hardware and software engineers to align mechatronic subsystems and automation platforms with assay requirements.

Benefits

• Competitive compensation
• Meaningful stock ownership
• Comprehensive benefits
• Great work environment

What This Job Offers

• Career Level: Senior
• Education Level: Master's degree
• Number of Employees: 11-50 employees