Senior Director, Pricing & Contracting

Zenas BioPharma • Waltham, MA

2d • Remote

About The Position

Zenas is a clinical-stage global biopharmaceutical company committed to becoming a leader in the development and commercialization of transformative therapies for patients with autoimmune diseases. Our core business strategy combines our experienced leadership team with a disciplined product candidate acquisition approach to identify, acquire and develop product candidates globally that we believe can provide superior clinical benefits to patients living with autoimmune diseases. Zenas is advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib. Obexelimab, Zenas’ lead product candidate, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. We believe that obexelimab’s unique mechanism of action and self-administered, subcutaneous injection regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Orelabrutinib is a potentially best-in-class, highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK) inhibitor with the potential to address compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Zenas’ earlier stage programs include a preclinical, potentially best-in-class, oral, IL-17AA/AF inhibitor, and a preclinical, potentially best-in-class, oral, brain-penetrant, TYK2 inhibitor. We are seeking top talent who share our commitment to patients and have a track record of success in acquiring, developing and commercializing products across the globe. Our colleagues have an opportunity to engage in a fast-paced learning environment and experience individual and organizational success as we work towards becoming a global immunology and autoimmune disease leader, while living our values of Transparency, Relationships, Urgency, Excellence and Innovation – TRUE Innovation ! Position Summary: The Senior Director, Pricing & Contracting is responsible for developing and leading the U.S. pricing and contracting strategy to support optimal market access, reimbursement, and financial performance for Zenas BioPharma’s portfolio, including development of contracting strategies with national/regional payer organizations, PBMs, and government payer segments. Reporting to the Vice President, U.S. Market Access, this role will lead the development of pricing strategy, gross-to-net modeling, and payer contracting strategies that support both product launch planning and lifecycle management. The Senior Director will play a key role in establishing launch pricing strategy while also overseeing ongoing pricing governance, access financial modeling, and contracting frameworks with payer organizations, pharmacy benefit managers (PBMs), and other healthcare stakeholders. This individual will work closely with the Payer Strategy team to support contract negotiations and ensure pricing and contracting decisions align with overall market access strategy and company financial objectives. This role will collaborate cross-functionally with Finance, Market Access, Legal, Compliance, Medical Affairs, and Commercial leadership to evaluate pricing scenarios, inform access strategy decisions, and support the successful commercialization of Zenas therapies. This role offers a unique opportunity to shape pricing and contracting strategy in preparation for upcoming product launches while supporting long-term access and financial performance for the Zenas portfolio.

Requirements

• Minimum of 12+ years of experience in the pharmaceutical or biotechnology industry, including at least 7+ years in Pricing, Contracting, Market Access, or Managed Markets roles.
• Demonstrated experience developing U.S. pricing strategy, including launch pricing recommendations and lifecycle pricing management for specialty or rare disease therapies.
• Proven experience developing and managing gross-to-net (GTN) models to support financial forecasting, pricing scenario planning, and contracting strategy.
• Demonstrated experience designing and implementing payer contracting strategies, including rebate structures and negotiations with pharmacy benefit managers (PBMs), national payer organizations, government payers and regional health plans.
• Strong understanding of U.S. pharmaceutical pricing dynamics, including WAC strategy, payer rebates, contracting frameworks, and market access considerations.
• Experience evaluating government pricing implications including AMP, Best Price, Medicaid rebate exposure, and 340B pricing considerations.
• Strong financial modeling and analytical skills with the ability to translate complex pricing and contracting scenarios into strategic recommendations.
• Demonstrated ability to collaborate cross-functionally with Market Access, Finance, Legal, Compliance, Medical Affairs, and Commercial teams.
• Strong leadership, communication, and executive presentation skills.
• Ability to operate effectively in a fast-paced and collaborative biotech environment.
• Willingness to travel as required to support contracting discussions and internal planning
• Bachelor’s degree required; advanced degree (MBA, MPH, PharmD or similar) preferred.

Nice To Haves

• Experience supporting product launches or late-stage pipeline assets strongly preferred.
• Experience supporting pricing governance processes and cross-functional pricing decision frameworks preferred.

Responsibilities

• Lead the development and execution of U.S. pricing strategy, including launch price recommendations and lifecycle pricing management for Zenas BioPharma’s portfolio.
• Develop and manage gross-to-net (GTN) models that support financial forecasting, access strategy decisions, and pricing scenario planning.
• Design and implement payer contracting strategies, including rebate structures and contracting frameworks with pharmacy benefit managers (PBMs), national payer organizations, and regional health plans.
• Partner with the Payer Strategy team to support contract negotiations and ensure pricing and rebate strategies align with payer coverage objectives.
• Lead financial modeling and pricing scenario analyses to evaluate the impact of pricing and contracting strategies on market access, reimbursement, and overall company financial performance.
• Collaborate closely with Finance to ensure pricing assumptions, GTN forecasts, and contracting scenarios are accurately reflected in financial planning and forecasting models.
• Monitor competitive pricing dynamics, payer contracting trends, and reimbursement environments to inform pricing strategy and market access planning.
• Support the development of pricing governance processes and provide strategic recommendations to senior leadership regarding pricing decisions and contracting strategies.
• Provide strategic pricing insights to support launch planning, payer engagement strategy, and long-term market access objectives.
• Provide strategic oversight of government pricing considerations, including AMP, Best Price, Medicaid rebate implications, and 340B pricing impacts, ensuring pricing and contracting strategies align with regulatory requirements.
• Partner with Legal and Compliance to ensure pricing and contracting practices adhere to regulatory requirements and company compliance standards.
• Collaborate cross-functionally with Market Access, Commercial, Medical Affairs, HEOR, and Finance teams to ensure alignment between pricing strategy, access strategy, and commercial objectives.
• Support the evaluation of pricing and contracting strategies across different payer segments, including commercial and government payer environments

Benefits

• The position is eligible for a competitive compensation and benefits package.
• Our base salary is just one component of Zenas’ competitive total rewards strategy that also includes annual performance bonus, equity, full range of benefits and other incentive compensation plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Number of Employees: 11-50 employees