Senior Director, Head of Antibody Conjugation DevelopmentNew

Immunome • Bothell, WA

405d • $235,000 - $275,000

About The Position

The Senior Director, Head of Antibody Conjugation Development at Immunome is a leadership role responsible for overseeing the development and optimization of antibody-drug conjugates (ADCs). This position plays a crucial role in strategic planning, project execution, and ensuring compliance with scientific and regulatory standards. The successful candidate will lead a team of scientists, drive innovation in conjugation technologies, and collaborate with cross-functional teams to advance the company's pipeline of targeted therapies for cancer treatment.

Requirements

• Ph.D. in Biochemistry, Chemistry, Molecular Biology, Chemical Engineering, or related field, with a focus on antibody conjugation or bioconjugates.
• Minimum of 12+ years of relevant experience in the biopharmaceutical industry, specifically in the development of antibody-drug conjugates (ADCs) or other conjugated biotherapeutics. A minimum of 5 years of leadership experience.
• Proven track record of leading successful conjugation development projects from early-stage research through late-stage development or commercialization.
• Experience working in a GMP environment and a strong understanding of regulatory requirements for bioconjugates.
• Excellent leadership, project management, and communication skills.

Nice To Haves

• In-depth understanding of the critical quality attributes (CQAs) of ADCs and bioconjugates, and experience with process development, scale-up, and tech transfer.
• Expertise in linker chemistry, conjugation techniques (e.g., cysteine/lysine conjugation), and bioconjugate characterization methods.
• Strong analytical and problem-solving abilities with a focus on innovation and continuous improvement.
• Excellent interpersonal skills and ability to work in a multidisciplinary team environment.
• Ability to manage multiple projects with tight deadlines and priorities.
• Strong strategic planning and decision-making skills.

Responsibilities

• Lead the antibody conjugation development team to design and optimize conjugation strategies for antibody-drug conjugates (ADCs).
• Oversee the development, scale-up, and transfer of conjugation processes to ensure robust and reproducible manufacturing processes.
• Drive innovation in conjugation technologies to improve conjugation specificity and efficiency to deliver safe and efficacious drug substances.
• Collaborate with cross-functional teams, including Analytical Development, mAb Process Development, Manufacturing, and Quality, to ensure seamless integration of conjugation strategies across all phases of development.
• Lead troubleshooting and process optimization efforts to resolve technical challenges related to conjugation, stability, and scalability.
• Generate suitable materials to support IND-enabling toxicology studies.
• Manage the preparation of technical reports, documentation, and regulatory submissions to support clinical development and commercialization.
• Stay current with industry trends, technologies, and regulatory requirements for antibody conjugation and bioconjugates.
• Mentor, develop, and manage a team of scientists, ensuring high performance and professional growth.
• Collaborate with external partners, contract development and manufacturing organizations (CDMOs) to support pipeline development and drive innovation in conjugation technologies.

Benefits

• Competitive salary range of $235,000 - $275,000 USD.
• Equal opportunity employer committed to diversity and inclusion.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree