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The Senior Director, Operational Quality is responsible for the Quality oversight of External Manufacturing operations for all Vertex Small Molecule programs, development and commercial. This is a critical role within Quality department responsible for developing and managing CDMO Quality relationships. The Sr. Director will also work closely with internal business stakeholders from Pharmaceutical Sciences, Commercial Manufacturing and Supply Chain as well as internal Quality functions to deliver quality outcomes. The Sr. Director is responsible for oversight of department activities, development of personnel and ensuring the quality of deliverables within the role's purview. The incumbent is known for significant technical expertise and establishes the strategic alignment of group and department goals with its projects and activities, refining and adapting as necessary through proactive monitoring/measurement. This position will be based in Vertex's corporate headquarters in Boston, MA. This is a hybrid role working 3 days on-site and up to two days remotely.