Senior Director, Global PF’4404

Pfizer • New York City, NY

2h • Hybrid

About The Position

At Pfizer Oncology, we are committed to “Outdo Cancer” by advancing transformative medicines wherever we can make a profound difference in the lives of patients. Today, Pfizer Oncology has an industry-leading pipeline that includes the combined legacy Pfizer and Seagen portfolio across breast, genitourinary, hematology-oncology and thoracic therapeutic areas. Thoracic represents a crucial component to achieve Pfizer’s overarching strategic ambition in Oncology; thoracic is estimated to represent ~25% of Pfizer Oncology’s 2030 global sales. Despite therapeutic advances in lung cancer, there remains significant unmet patient need. Each year, there are over 2.5 million new lung cancer diagnoses globally. The lung cancer therapies market is expected to grow from $45B in 2025 to $70B in 2030 globally. Collectively, our focus is on building upon our foundation in lung precision medicine to accelerate new standards of care in broader populations. Pfizer’s lung cancer portfolio is well-positioned to leverage the potential clinical synergy between vedotin antibody drug conjugates (ADCs) and checkpoint inhibitors and to differentiate with novel combination therapies. In July 2025, Pfizer completed the global, ex-China, licensing agreement with 3SBo, Inc. granting Pfizer exclusive rights for the development, manufacturing and commercialization of 3SBio’s SSGJ-707, a bispecific antibody targeting PD-1 and VEGF developed using 3SBio’s proprietary CLF2 platform. SSGJ-707 or PF’4404 aims to displace standard of care PD-1/L1 and VEGF therapies. Several key Phase 3 trial study starts were achieved in 2025, Phase 3 1L squamous and non-squamous NSCLC, Phase 2 / 3 1L ES-SCLC and Phase 3 1L mCRC. This role provides an excellent opportunity to shape the 4404 commercial potential. In Global Marketing, we translate science into value for patients. Our remit is to own the strategic direction across the asset lifecycle, ensure long-term value creation and preservation, and drive brand consistency across markets and efficiencies in execution. This role will report to the Vice President, Global Franchise Lead for Hematology, Thoracic and Gastrointestinal.

Requirements

• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
• Bachelor’s degree
• 12+ years of commercial experience in the pharmaceutical industry
• Expertise in global pharmaceutical/biotech
• Ability to work independently across senior level stakeholders and demonstrates judgement of what needs to be escalated
• Strong team player with demonstrated ability to engage experts from a wide range of functional areas to improve business performance and find a path forward
• Strong strategic thinking, analytical skills, detail and action oriented, creative, flexible, self-motivated
• Proven track record of translating key insights into meaningful strategies and tactics
• Excellent verbal and written communication skills for a wide range of audiences
• Solid understanding of today’s Global and US pharmaceutical environment, including Regulatory, Legal and Compliance
• Is a role model for the Pfizer Values

Nice To Haves

• Advanced degree
• Commercial strategy, launch, and lifecycle management experience

Responsibilities

• Shape PF'4404 global commercial strategy and launch strategy, inclusive of brand positioning and messaging, market development.
• Represent Global Commercial voice and point of view on PF'4404 Global Product Team (GPT) and partner closely with CSI, Clinical Development, Regulatory, Global Access & Value, Global Medical Affairs to ensure key opportunities and risks in the clinical development plan meet the target product profile and incorporate commercial insights from inline/launch experiences in lung cancer, colorectal cancer, and endometrial cancer.
• Partner with CSI to drive thought leadership on lifecycle commercial potential, including key risk/opportunity identification that factors competitive landscape dynamics, to ensure value creation for the mid-to-long term horizon
• Contribute to Global Thoracic Commercial Strategy in partnership with fellow Global Commercial Leads to ensure aligned portfolio positioning and brand positioning
• Ensure proactive translation of key competitive intelligence insights into action; and prepare senior leadership communications when appropriate.
• Conduct all activities and make decisions that are in accordance with Company policies and SOPs, Pfizer Values & global regulatory guidelines, and requests consultation when navigating uncertain situations.

Benefits

• We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments.
• Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level