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Memorial Sloan Kettering Cancer Center (MSK) is seeking a Senior Director, Core Infrastructure to lead enterprise infrastructure strategy, architecture, infrastructure engineering, and operations across on-premises, hybrid, and cloud environments. This leadership role focuses on ensuring infrastructure stability, security, scalability, and alignment with business goals through automation, operational excellence, and innovation. The Senior Director will define and execute a long-term roadmap for networking, hosting, cloud integration, and enterprise services, overseeing one of the largest budgets within Enterprise Technology Services (ETS). This individual will lead critical initiatives such as network redesign, omni-cloud implementation, and next-generation security frameworks, driving the performance and resilience of MSK's technology ecosystem.