Senior Director, Clinical Scientist

Kymera Therapeutics • Watertown, MA

2d • $235,000 - $330,000

About The Position

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.
How we work:
PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.
How you’ll make an impact:
Contribute to the creation, design, and execution of Kymera’s clinical development strategy, collaborating with cross-functional teams (Biometrics, Regulatory, Clinical Operations) and external advisors.
Provide scientific leadership from clinical trial design and protocol development, ensuring operational feasibility, data quality, and participant/site engagement.
Ensure patient safety and data accuracy and integrity by conducting medical and clinical data reviews, monitoring protocol adherence, and managing protocol deviations.
Collaborate across functions to ensure timely, high-quality study delivery and successful execution of clinical programs.
Lead or contribute to creating essential documents such as Investigator’s Brochures and safety updates and serve as subject matter expert for regulatory submissions and interactions with regulatory authorities.
Drive improvement and innovation of clinical development practices and maintain consistency across studies.
Engage with KOLs, academic collaborators, and external experts to guide program direction.
Mentor and grow high-performing teams in a fast-paced, entrepreneurial environment.
Stay current on disease biology, therapeutic practices, and drug mechanisms of action, providing insights into the competitive landscape and strategic development pathways.
Contribute to the preparation of scientific materials for conferences, publications, and presentations, supporting internal and external communication.

Requirements

• A Bachelor’s Degree is required, with an advanced degree in life sciences or healthcare (PhD, MD, PharmD, MSc or equivalent) preferred. Significant experience in late-stage drug development is highly desirable.
• 10+ years of experience in clinical trial planning, startup, execution, reporting, and publishing within the biotech/pharma industry. Experience in immunology, inflammation, or related therapeutic areas is a plus.
• Proven leadership in clinical strategy, development and execution of innovative clinical development plans.
• Demonstrated expertise in protocol development, study report and investigator brochure (IB) authoring, and preparing regulatory submissions.
• Proven track record of successfully collaborating with medical monitors, development operations, and clinical investigators.
• Thorough knowledge of relevant regulatory guidelines, including GCP, ICH, and FDA standards, as well as a strong understanding of Quality practices within GCP.
• Highly analytical and organized, with strong critical thinking skills and a history of innovative problem-solving.
• Experience managing multiple tasks and priorities, especially under tight deadlines, with a keen attention to detail.
• Ability to work independently, in multi-disciplinary teams, and with external partners, demonstrating strong interpersonal skills.
• Exceptional communication skills, both written and verbal, with the ability to convey complex information clearly to diverse audiences.
• Strong influencing abilities, with a history of resolving complex issues in creative and effective ways, and the capability to lead cross-functional teams.

Nice To Haves

• Significant experience in late-stage drug development is highly desirable.
• Experience in immunology, inflammation, or related therapeutic areas is a plus.

Responsibilities

• Contribute to the creation, design, and execution of Kymera’s clinical development strategy, collaborating with cross-functional teams (Biometrics, Regulatory, Clinical Operations) and external advisors.
• Provide scientific leadership from clinical trial design and protocol development, ensuring operational feasibility, data quality, and participant/site engagement.
• Ensure patient safety and data accuracy and integrity by conducting medical and clinical data reviews, monitoring protocol adherence, and managing protocol deviations.
• Collaborate across functions to ensure timely, high-quality study delivery and successful execution of clinical programs.
• Lead or contribute to creating essential documents such as Investigator’s Brochures and safety updates and serve as subject matter expert for regulatory submissions and interactions with regulatory authorities.
• Drive improvement and innovation of clinical development practices and maintain consistency across studies.
• Engage with KOLs, academic collaborators, and external experts to guide program direction.
• Mentor and grow high-performing teams in a fast-paced, entrepreneurial environment.
• Stay current on disease biology, therapeutic practices, and drug mechanisms of action, providing insights into the competitive landscape and strategic development pathways.
• Contribute to the preparation of scientific materials for conferences, publications, and presentations, supporting internal and external communication.

Benefits

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $235,000 – $330,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Number of Employees: 101-250 employees