Senior Director, Architecture – Enterprise and Strategy, Alexion

AstraZeneca • Boston, MA

2d • $283,851

About The Position

Shape the Future of Enterprise Architecture with AI at Alexion

At Alexion, part of AstraZeneca, we are reimagining how technology powers life-changing medicines. As Senior Director, Architecture, you will lead the strategic design and evolution of our enterprise architecture, driving transformation across business and IT landscapes. This is not just a leadership role—it’s a chance to define how AI and advanced analytics reshape the way we deliver value to patients worldwide.
Our Mission:
We are driven to transform the lives of people affected by rare diseases and devastating conditions through the development and delivery of life-changing medicines. Your work will enable this mission by creating a technology foundation that accelerates innovation and improves patient outcomes.
Why this role matters:
Enterprise Architecture is at the heart of our digital strategy. With AI accelerating innovation, this role is critical to ensuring our architecture is future-ready—enabling agility, scalability, and data-driven insights across the organization. You will champion standards, patterns, and roadmaps that unlock AI-powered capabilities, guiding Alexion toward a smarter, more connected enterprise.

Requirements

• Minimum bachelor’s degree in computer science, engineering, information technology or equivalent
• + 10 experience in Enterprise Architecture leadership roles.
• Expertise in cloud-native strategies (AWS, Azure, MultiCloud) and data architecture.
• Strong understanding of AI, machine learning, and data modeling technologies.
• Proven ability to influence senior stakeholders and deliver transformation at scale.
• High emotional intelligence, adaptability, and strategic vision.

Responsibilities

• Set the vision and strategy for enterprise architecture, aligning with business priorities and AI-driven transformation.
• Define and enforce architecture standards, patterns, and roadmaps across cloud, data, and application domains.
• Partner with senior business and IT leaders to integrate AI into architecture blueprints, enabling predictive analytics and intelligent automation.
• Lead a team of architects to deliver end-to-end solutions that simplify complexity and accelerate innovation.
• Act as a strategic advisor on architecture decisions, ensuring compliance, cost efficiency, and adoption of emerging technologies.
• Drive continuous improvement of architecture capabilities, fostering best practices and thought leadership.

Benefits

• competitive compensation
• comprehensive benefits
• opportunity to make a real impact on patients’ lives
• opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles
• qualified retirement programs
• paid time off (i.e., vacation, holiday, and leaves)
• health, dental, and vision coverage in accordance with the terms of the applicable plans

What This Job Offers

• Job Type: Full-time
• Career Level: Director