Senior Data Manager, Clinical Data Management
About The Position
We are looking for a Senior Clinical Data Manager who can independently lead data management for multiple cognitive and psychiatric clinical studies. This is a senior-level, hands-on role for someone who thrives in a fast-paced environment, can run studies end-to-end, and partners closely with cross-functional teams to deliver high-quality, analysis-ready data. As the Senior Clinical Data Manager, you will own all data management activities from study start-up through database lock, including: Leading data management for multiple clinical trials with minimal oversight. Serving as the primary CDM lead for internal teams, CROs, and external vendors. Designing eCRFs and overseeing database build, UAT, and system release. Developing and executing core DM documents (e.g., Data Management Plan, edit checks, reconciliation plans, CRF guidelines). Managing data cleaning, query review, external data integration, and database quality checks. Driving database lock and ensuring submission-ready data packages. Collaborating with Clinical Ops, Biostats, Data Engineering, and Data Science to ensure data quality and readiness. Ensuring compliance with ICH-GCP, FDA, GDPR, HIPAA, and internal standards. Contributing to process improvement and helping scale CDM capabilities across Altos portfolio. This role requires someone who is confident leading studies independently, setting timelines, managing vendors, and driving deliverables to completion.
Requirements
- 7+ years of clinical data management experience, including 3+ years in a senior/lead role.
- Proven ability to independently run studies from protocol review through database lock.
- Experience managing CROs, EDC systems, and external data vendors.
- Strong understanding of CDISC standards (CDASH, SDTM) and DM best practices.
- Excellent communication, problem-solving, and project management skills.
- A passion for advancing data-driven clinical research.
Nice To Haves
- Experience in neuroscience, psychiatry, or cognitive health is a plus.
- Familiarity with SAS, SQL, Python, or similar tools is beneficial.
Responsibilities
- Leading data management for multiple clinical trials with minimal oversight.
- Serving as the primary CDM lead for internal teams, CROs, and external vendors.
- Designing eCRFs and overseeing database build, UAT, and system release.
- Developing and executing core DM documents (e.g., Data Management Plan, edit checks, reconciliation plans, CRF guidelines).
- Managing data cleaning, query review, external data integration, and database quality checks.
- Driving database lock and ensuring submission-ready data packages.
- Collaborating with Clinical Ops, Biostats, Data Engineering, and Data Science to ensure data quality and readiness.
- Ensuring compliance with ICH-GCP, FDA, GDPR, HIPAA, and internal standards.
- Contributing to process improvement and helping scale CDM capabilities across Altos portfolio.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
No Education Listed
