Senior Computational Biologist

Pfizer • Cambridge, MA

2d • Hybrid

About The Position

Pfizer’s Machine Learning and Computational Sciences group is seeking a highly skilled computational biologist with experience in bioinformatics workflow and data management method development. The role involves analyzing high-throughput sequencing and multi-omics data to support the development of analytical assays and the characterization of oligonucleotide-based therapeutics. The successful candidate will be responsible for developing statistically rigorous analytical methods and building and managing both internal and publicly available databases. This will be achieved through close collaboration with a diverse community of experimental scientists across various research sites. This position requires a strong educational and research background in both computational biology and biostatistics in addition to a thorough understanding of molecular biology. The ideal candidate will demonstrate enthusiasm for working collaboratively, communicating effectively, and engaging with both computational and experimental scientists to drive innovation and analytical excellence.

Requirements

• Ph.D. degree in computational biology, biostatistics, computer science, or a related technical field with 0-5 years of industrial experience in the analysis of high-throughput sequencing and other omics datasets.
• Demonstrated high proficiency in programming, with strong skills in Python and workflow languages to efficiently execute and automate workflows and data management tasks.
• Experience in computational tool and package development including version control, unit testing, deployment, and documentation.
• A strong interest in continuously learning and engaging with emerging biological initiatives.
• Attention to detail, documentation skills, ability to multitask, and effective interpersonal and presentation skills.

Nice To Haves

• Extensive experience in developing high-throughput sequencing pipelines using the Nextflow workflow development language on a cloud-based platform.
• An in-depth understanding of the statistical methods commonly used in omics analyses.
• Familiarity with cGMP regulatory requirements for data and infrastructure security controls.
• Experience analyzing nucleic acid molecules, large molecules, and vaccines.
• A strong record of well-cited journal publications and presentations.

Responsibilities

• Develop computational methods and workflows to support Pfizer’s portfolio projects focused on nucleic acid products and medicines.
• Streamline and automate complex analytical tasks for short-read and long-read sequencing data to improve efficiency and maintain reproducibility.
• Provide support for data analysis, visualization, interpretation of results, and experimental design feedback across multiple projects.
• Conduct detailed bioinformatics and statistical analyses and maintain documentations within a regulated system.
• Work closely with Research & Development scientists to generate new scientific insights.
• Manage and maintain computational infrastructure and database systems.

Benefits

• participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program.
• comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments.
• Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees