Senior Clinical Trial Manager

Kymera Therapeutics•Watertown, MA

5d•$145,000 - $215,000

About The Position

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. Under the leadership of the Director, Clinical Operations, drives end-to-end trial execution, ensuring operational quality, adherence to budget and timelines, and achievement of activation and recruitment goals. Proactively identifies and mitigates risks to study delivery. Leads the planning and execution of study-specific meetings (e.g., internal team meetings, investigator meetings, risk reviews, lessons learned), ensuring alignment and progress across stakeholders. Oversees CRO and vendor performance (e.g., eCOA, IRT, central labs), setting clear expectations, managing deliverables, and serving as the primary point of contact and subject matter expert. Contributes to vendor selection, specifications, UAT, and ongoing oversight. Leads or contributes to the development and review of key study documents, including the Clinical Study Protocol, informed consent forms, Clinical Trial Oversight Plan, Pharmacy Manual, and applicable study plans across Kymera and CRO. Provides oversight of data quality and integrity, including input into eCRFs, edit checks, and data review plans; monitoring data entry and query resolution; and driving data cleaning strategies in collaboration with Data Management, Medical, and Safety to support timely analyses and database locks. Ensures effective clinical and monitoring oversight through review of monitoring outputs (e.g., reports, central monitoring, protocol deviations, medical data), identifying trends, escalating issues, and implementing corrective actions as needed. Performs Clinical Monitoring Oversight Visits when required. Ensures inspection readiness and compliance with the Clinical Trial Oversight Plan, ICH/GCP, and applicable regulatory requirements, including oversight of eTMF quality and completeness and support of CTA activities. Builds and maintains strong relationships with investigators and site staff, representing Kymera at key study events such as SIVs. Contributes to continuous process improvement initiatives at both the study and department level. This role may require up to 25% travel.

Requirements

8+ years working in clinical research (CRO, Biotech or Pharmaceutical organization), with at least 3 years of experience at a sponsor organization in a Clinical Trial Manager position.
Experience leading Ph2 and/or Ph3 trials from RFP to CSR.
Strong knowledge of regulatory and ICH GCP guidelines, CFR, HIPAA, Protection of Human Research Subjects, GDPR.
Strong project management skills with the ability to manage multiple trials simultaneously.
Excellent problem-solving, leadership, and communication skills.
Ability to work in a fast-paced, dynamic environment with cross-functional teams.

Nice To Haves

Respiratory or Immunology experience highly preferred.

Responsibilities

Drives end-to-end trial execution, ensuring operational quality, adherence to budget and timelines, and achievement of activation and recruitment goals. Proactively identifies and mitigates risks to study delivery.
Leads the planning and execution of study-specific meetings (e.g., internal team meetings, investigator meetings, risk reviews, lessons learned), ensuring alignment and progress across stakeholders.
Oversees CRO and vendor performance (e.g., eCOA, IRT, central labs), setting clear expectations, managing deliverables, and serving as the primary point of contact and subject matter expert. Contributes to vendor selection, specifications, UAT, and ongoing oversight.
Leads or contributes to the development and review of key study documents, including the Clinical Study Protocol, informed consent forms, Clinical Trial Oversight Plan, Pharmacy Manual, and applicable study plans across Kymera and CRO.
Provides oversight of data quality and integrity, including input into eCRFs, edit checks, and data review plans; monitoring data entry and query resolution; and driving data cleaning strategies in collaboration with Data Management, Medical, and Safety to support timely analyses and database locks.
Ensures effective clinical and monitoring oversight through review of monitoring outputs (e.g., reports, central monitoring, protocol deviations, medical data), identifying trends, escalating issues, and implementing corrective actions as needed. Performs Clinical Monitoring Oversight Visits when required.
Ensures inspection readiness and compliance with the Clinical Trial Oversight Plan, ICH/GCP, and applicable regulatory requirements, including oversight of eTMF quality and completeness and support of CTA activities.
Builds and maintains strong relationships with investigators and site staff, representing Kymera at key study events such as SIVs.
Contributes to continuous process improvement initiatives at both the study and department level.

Benefits

Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.

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