Senior Associate Scientist

Regeneron Pharmaceuticals • Tarrytown, NY

78d • $79,100 - $129,100 • Remote

About The Position

Regeneron Pharmaceuticals, Inc. seeks a Senior Associate Scientist (Tarrytown, NY) to develop and characterize cellular and animal models to test novel therapeutics. Collect disease-relevant tissue from animal models of neurodegenerative disease and downstream processing including biochemical analysis, tissue sectioning, immunohistochemistry, and microscopy. Design and implement cell-based assays, and other novel technologies to better understand the mechanisms of neurodegeneration. Analyze and evaluate data. Participate in research studies designed to understand the biology behind various neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis. Present data both internally and externally, and participate in discussions in collaborative, cross-functional team environment. Local telecommuting permitted up to 1 day per week.

Requirements

• Bachelor's degree in Biology, Molecular Biology, Neuroscience, Biotechnology or related field.
• 1 year of experience in the biotechnology industry.
• Experience with supporting the development and characterization of novel cellular and mouse models of neurological and neurodegenerative disease.
• Handling of neonatal and adult mice with practical understanding of mouse anatomy.
• Intracerebroventricular (ICV) injection of adeno-associated virus (AAV) into neonatal mouse pups.
• Mouse dissection including microdissection of sub-regions of CNS tissue.
• Processing cell and tissue samples for various biochemical analysis including Western blot analysis.
• Experience with automated capillary gel electrophoresis systems such as ProteinSimple Wes and PeggySue systems, ELISA, and MSD.
• DNA and RNA isolation and real-time quantitative PCR (qPCR) analysis.
• Downstream processing of mouse tissue, encompassing sectioning, immunostaining, immunohistochemistry, and advanced microscopy techniques.
• Utilizing in vitro cell culture systems, including transformed cell lines and human induced pluripotent stem cells (iPSCs).
• Conducting data analysis and evaluation using software such as Halo, GraphPad Prism, Microsoft Excel and PowerPoint.
• Compiling data into presentation formats and presenting work both internally and externally.

Responsibilities

• Develop and characterize cellular and animal models to test novel therapeutics.
• Collect disease-relevant tissue from animal models of neurodegenerative disease.
• Perform downstream processing including biochemical analysis, tissue sectioning, immunohistochemistry, and microscopy.
• Design and implement cell-based assays and other novel technologies.
• Analyze and evaluate data.
• Participate in research studies on neurodegenerative diseases.
• Present data internally and externally.
• Engage in collaborative, cross-functional team discussions.

Benefits

• Health and wellness programs
• Fitness centers
• Equity awards
• Annual bonuses
• Paid time off for eligible employees

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree