Senior Associate Scientist, Protein Analytical Development

Vaxcyte•San Carlos, CA

2d•$118,000 - $138,000•Onsite

About The Position

Vaxcyte is looking for a highly skilled, motivated, and talented contractor to join Vaxcyte’s Vaccine Product Development organization as a Senior Associate Scientist (contract) within Protein Development and Clinical Manufacturing. The contractor will assume an important role of development and executing the key analytical methods to support the measurement of titer, impurities and product quality for in-process intermediates. The successful candidate will support the setup of analytical capabilities within protein process development group, perform the method qualification of in process analytical methods and apply the methods for process characterizations. This position is for a scientific role which will be lab based, and will require excellent scientific judgment, independence, precise and consistent data generation and thorough record keeping.

Requirements

B.S. in Chemistry, Analytical Chemistry, Biochemistry, or related field with minimum 5 years relevant industry experience; MS with minimum 3 years industry experience in Pharma/Biotech industry required.
Strong technical understanding in analytical chemistry.
Hands on proficiency and with protein analysis using HPLC, CE-SDS, Western blotting, Spectroscopy, etc.
Perform accurate and reliable data analysis and interpretation of experimental results related to process characterization.
Ability to think critically and demonstrate troubleshooting and problem-solving skills.
Maintain accurate records of experimental procedures, results and conclusion in compliance with regulatory guidelines.
Team player, proactive and willing to work in a collaborative team environment.
Scientific creativity and curiosity for applying new technologies to complex analytical challenges.

Responsibilities

Assist in setting up instrument capabilities to enable the analytical methods development and qualification for protein process characterization.
Perform protein analysis using HPLC (size exclusion, ion exchange, reversed phase , etc ), CE-SDS, CE-Lif, PicoGreen and Bradford assay, Capillary Western (Jess and Leo), A280 and SoloVPE.
Acquire and interpret data for protein titer, molecule characterization for protein process development studies with precision and accuracy.
Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports.
Assist in troubleshooting of instrumentation and test results.
Able to work well independently and in a team setting on assigned tasks, such as method development and sample testing.
Participate in group meetings, present results of work, interpret data, and report results in an accurate manner.
Work with lab automation to create high throughput methods leveraging liquid handling and robotic technologies.
Work in collaboration with other scientists/SME to design experiments and advance more powerful analytical techniques.