Senior Associate Scientist, Invivo Oncology Discovery

Bristol Myers Squibb • VA

85d • $105,040 - $127,287

About The Position

The successful candidate will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early-stage therapeutics in Oncology TRC. The position will utilize in-vivo models to profile novel biologics like T cell engagers. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in Discovery Oncology, protein engineering/antibody development, DMPK and translational group. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Requirements

• A B.S. with 2-7 years relevant industry or comparable academic experience and a clearly demonstrated skill set in in vivo oncology or cancer cell signaling is required.
• Demonstrated competency in independently using in vivo mouse tumor models to perform PK/PD and efficacy studies in conjunction with blood/tissue collection is required.
• Experience with subcutaneous syngeneic and xenograft tumor models is required; experience with GEMMs and PDx models is a plus.
• Competency in murine dosing, i.e. PO, IP, IV, SC, is required; intra-tumor and IM is preferred.
• Proficiency in cell culture, passaging and harvesting is required.
• Experience with preparing adherent and suspension mammalian cells for subcutaneous and intravenous implantation preferred.
• Experience in independently processing blood samples, harvesting and disaggregating tumors, spleen and preparing samples for FACS analysis.
• Independently set up FACS multichannel panels and routinely profile tumors, blood and lymphoid organs by Flow cytometric analysis.
• Demonstrated experience executing ex vivo assays to investigate target engagement, mechanism of action and biomarkers by qPCR, ELISA (MSD), WB.
• Familiar with cytokine profiling studies and analysis by MSD & Luminex methods.
• Experience with orthotopic or chemically induced mouse models or rodent surgical experience is a plus.
• Proficiency in utilizing software such as GraphPad Prism™, electronic notebooks, Microsoft office etc. for data analysis and figure generation is required.
• Excellent organizational skills and a detail-oriented approach to the execution of experiments and record keeping is a requirement.
• Strong interpersonal skills with the ability to interact effectively with peers and management is required.

Responsibilities

• Independently conduct mouse in vivo pharmacology experiments, including but not limited to model development, tumor implantation, dosing via IV, IP, SC, I-TUMOR, IM and PO routes, tumor measurements, health monitoring, tissue sampling by fine needle biopsy and core needle biopsy, peritoneal lavage, blood draws by retro-orbital, tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses.
• Independently conduct in vivo efficacy and PK/PD studies and experiments supporting the development of new pharmacology models.
• Contribute to the utilization of ELISAs (MSD), qPCR, or WB to monitor biomarkers and cytokines in harvested tissues & blood samples.
• Isolate PBMC and primary T cells from Leukopaks and functionally characterize them using cell-based assays.
• Contribute to the utilization of multi-color flow cytometry to profile the immune infiltrate in harvested mouse tissues.
• Accurately maintain proper scientific documentation associated with pharmacology studies in an electronic lab notebook.
• Effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers.
• Rotating weekends, holidays and off-hour on-site responsibilities to support in life studies, when applicable.

Benefits

• Medical, pharmacy, dental and vision care.
• Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
• Financial well-being resources and a 401(K).
• Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
• Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
• Parental, caregiver, bereavement, and military leave.
• Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
• Other perks like tuition reimbursement and a recognition program.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Bachelor's degree
• Number of Employees: 5,001-10,000 employees