Senior Applied AI Engineer

Komodo Health•San Francisco, CA

5d•$191,000 - $253,000•Hybrid

About The Position

At Komodo Health, our mission is to reduce the global burden of disease. And we believe that smarter use of data is essential to this mission. That’s why we built the Healthcare Map — the industry’s largest, most complete, precise view of the U.S. healthcare system — by combining de-identified, real-world patient data with innovative algorithms and decades of clinical experience. The Healthcare Map serves as our foundation for a powerful suite of software applications, helping us answer healthcare’s most complex questions for our partners. Across the healthcare ecosystem, we’re helping our clients unlock critical insights to track detailed patient behaviors and treatment patterns, identify gaps in care, address unmet patient needs, and reduce the global burden of disease. As we pursue these goals, it remains essential to us that we stay grounded in our values: be awesome, seek growth, deliver “wow,” and enjoy the ride. At Komodo, you will be joining a team of ambitious, supportive Dragons with diverse backgrounds but a shared passion to deliver on our mission to reduce the burden of disease — and enjoy the journey along the way. The Opportunity at Komodo Health: Healthcare in the U.S. is a mess. Komodo Health is fixing that—with data. We’ve mapped the patient journey across the country to build the most complete picture of disease burden and treatment gaps. Our customers—pharma companies, payers, and health systems—use this data to make decisions that meaningfully improve patient outcomes. Labs@Komodo builds the AI-native platforms and systems that turn this data into action. We are the team behind Marmot, Komodo’s AI-native product—designed with AI embedded directly into both the interface and the development workflow. By combining Komodo’s unmatched healthcare data with modern LLMs, marmot is delivering some of the most compelling real-world insights of the new AI era. Mission of the Role: As a Senior Applied AI Engineer, you own complex, full-stack AI solutions end-to-end—from applied research to production deployment. This role exists to set technical direction for ambiguous and high-impact use cases across Komodo, while scaling the AI systems, patterns, and infrastructure that enable reliable, repeatable delivery. You’ll mentor others, lead architectural decisions, and deepen Komodo’s AI-first culture. Looking back on your first 12 months at Komodo Health, you will have accomplished… Shipped production-grade, full-stack AI solutions that materially enhance Komodo’s platform precision, reliability, or scalability. Led design and architecture for complex AI systems, including multi-agent orchestrations and advanced model pipelines. Prototyped and validated new applied research techniques, bringing academic insights into practical implementation. Designed A/B experiments and evaluation frameworks to measure AI impact in production. Mentored engineers across teams in prompt engineering, debugging, agent orchestration, and AI system design. Influenced MLOps pipeline improvements (model versioning, automated monitoring, CI/CD for AI).

Requirements

Proven track record of building end-to-end, production-grade AI systems.
Expertise with LLMs, agent orchestration, multi-agent systems, and advanced prompt engineering.
Strong fluency in Python and modern GenAI frameworks (vLLM, Crew AI, Strands, Chat Completions API).
Full-stack depth enabling seamless integration of AI across front-end and back-end systems.
Experience designing experiments, A/B tests, evaluation metrics, and performance instrumentation.
Experience collaborating with platform/infrastructure teams on MLOps workflows.
Strong cross-functional communication and mentorship capability.
You will drive experimentation across the organization, set best practices, and integrate new AI techniques into Komodo’s broader engineering ecosystem.

Nice To Haves

Healthcare data expertise.
Experience with distributed computing frameworks (e.g., Spark, Snowflake, Databricks) for large-scale data processing.

Responsibilities

Architecting, building, and deploying end-to-end AI systems that balance innovation with reliability and ethical considerations.
Leading solution design for ambiguous AI problems across Komodo’s platform and internal operations.
Collaborating with product, data, and platform teams to define requirements and shape strategic AI investments.
Designing advanced prompt chains, multi-agent flows, and complex evaluation frameworks.
Driving applied research by experimenting with cutting-edge models, techniques, and academic papers.
Contributing to internal AI standards, reusable templates, and high-performance orchestration patterns.
Transitioning prototypes into scalable systems with comprehensive observability, alerting, and governance.

Benefits

Positions may be eligible for company benefits in accordance with Company policy.
We offer a competitive total rewards package including medical, dental and vision coverage along with a broad range of supplemental benefits including 401k Retirement Plan, prepaid legal assistance, and more.
We also offer paid time off for vacation, sickness, holiday, and bereavement.
We are pleased to be able to provide 100% company-paid life insurance and long-term disability insurance.

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