Scientist

Bruker Corporation-posted 9 days ago
Full-time • Mid Level
Emeryville, CA
5,001-10,000 employees
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At Bruker Cellular Analysis (BCA), we create products using advanced optofluidic technology that enable customers to interrogate and recover individual cells for downstream molecular analysis. Our platforms, including the Beacon® Optofluidic System, leverage proprietary Opto-Electropositioning (OEP™) technology to automate complex cellular workflows with unprecedented precision and speed. We are expanding our Next-Generation Sequencing (NGS) capabilities to connect single-cell functional assays with genomic insights. As an NGS Scientist, you will develop and refine Illumina-based sequencing workflows that enable customers and internal R&D teams to translate single-cell biology into high-quality molecular data Responsibilities This position resides at the interface of Applications R&D, Molecular Biology, Bioinformatics, and Product Development. You will collaborate closely with cell biologists, engineers, assay developers, and bioinformaticians to implement robust, scalable sequencing workflows for product and application development. We welcome collaborative, detail-oriented scientists who thrive in multidisciplinary environments and want to help shape the next generation of cellular analysis technology.

  • Develop and optimize Illumina NGS library preparation workflows (DNA and RNA) for single-cell and bulk assays.
  • Integrate sequencing workflows into existing and emerging Beacon® applications for antibody discovery, functional genomics, and cell therapy research.
  • Design, execute, and analyze sequencing experiments to evaluate workflow performance and enable new product capabilities.
  • Establish and maintain QC metrics across the NGS pipeline, from input quality to sequencing readouts.
  • Collaborate with automation and software engineering teams to implement scalable, reproducible sequencing workflows.
  • Support root-cause investigations and troubleshooting of sequencing-related issues and contribute to continuous process improvement.
  • Maintain accurate and complete documentation (SOPs, protocols, technical reports) in accordance with internal quality systems.
  • Communicate experimental results, recommendations, and data insights to cross-functional project teams.
  • M.S. or Ph.D. in Molecular Biology, Genomics, Bioengineering, or a related field (or equivalent industry experience).
  • 2+ years of hands-on experience with Illumina sequencing workflows, including library prep, sequencing, and data QC.
  • Strong understanding of nucleic acid biochemistry and standard molecular biology techniques (enzymatic reactions, purification, quantification).
  • Familiarity with single-cell sequencing, immune repertoire profiling, or multi-omic workflows.
  • Experience with sequencing QC instrumentation (Bioanalyzer, TapeStation, qPCR, fluorometric assays).
  • Ability to interpret sequencing quality metrics and identify technical or process-related issues.
  • Excellent communication skills and the ability to collaborate in a fast-paced, interdisciplinary environment.
  • Experience with automated NGS workflows (Agilent Bravo, Hamilton STAR, etc.) or high-throughput assay development.
  • Exposure to basic bioinformatics tools (e.g., demultiplexing, alignment, QC review) or scripting in Python/R.
  • Experience working within a QMS, ISO 13485, or regulated product development environment.
  • 401(k) with company match
  • an employee stock purchase plan
  • medical and dental plans
  • life insurance
  • short-term and long-term disability insurance
  • employee assistance program
  • paid time off including vacation, sick time and holidays
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