Scientist

Gilead Sciences•Oceanside, CA

8d•Onsite

About The Position

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The successful candidate will possess a detailed understanding of proteins and carbohydrates. The candidate must be highly motivated to contribute to the research and development of biologics targeting unmet medical needs through biochemical characterization and novel method development supporting clinical and commercial programs. Experience in several of the following fields is strongly desired: analytical chemistry, biochemistry, biological mass spectrometry, high performance or ultra-performance liquid chromatography, electrophoretic separations, enzymology, statistics, chemical and biophysical structural elucidation, and bioinformatics. The position will be on-site in Oceanside with a future transfer to Foster City.

Requirements

PhD in Chemistry or a related discipline with limited industry experience or BS or MS degree with extensive industry experience.
Strong knowledge in mass spectrometry, experimental design, and assay development.
Excellent communication skills (both verbal and technical) and interpersonal skills are required.
Must be able to participate in highly effective teams.
Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
The candidate will be expected to work in a matrixed environment and be an effective communicator of ideas, assay results and issues.

Nice To Haves

Familiarity with several of the following is highly desired: Peptide mapping by LC-MS/MS, intact mass analysis, MS/MS for protein and carbohydrate structural elucidation/quantification, kinetic analyses, ultra-performance chromatography, and proteolytic/chemical processing.
Knowledge of ICH guidelines and GMP is a plus.
Expertise in mass spectrometry analysis software (Protein Metrics, Thermo BioPharma Finder and Skyline) and data analysis/visualization tools (Python, R, JMP, and Spotfire).

Responsibilities

Works as part of a team to support late-stage assay development by performing mass spectrometry to characterize molecules, degradation pathways, and define critical quality attributes in a phase-appropriate context.
Contributes to analytical method development and qualification to support protein characterization activities.
Supports comparability and stability studies by mass spectrometry.
Operates, maintains, and troubleshoots Waters and Bruker QTOFs and Thermo Orbitrap mass spectrometers.
Works on moderately complex problems where analysis of situations or data requires evaluation of intangible variables requiring regular use of intelligence, logic, ingenuity, and creativity.
Works in collaboration with junior and senior team members to advance the development of state-of-the-art techniques to characterize substances, assays, and tools.
Represents the Structure Characterization group in cross-functional project teams.
Participates in technology transfer of assays from analytical development to QC and external CRO/CMOs.
Participates in process comparability studies and coordinates analysis of in-process and product-related impurities as needed.
Responsible for conducting scientific research for the development of drug candidates or research support of marketed drugs.
Advises project teams on the planning and execution of laboratory experiments, considering economic, regulatory and safety factors.
Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
Maintains familiarity of state-of-the art scientific principles and literature and applies such knowledge appropriately to projects and in support of the Company’s interests.
Represents the company at national/international conferences.

Benefits

This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package.
Benefits include company-sponsored medical, dental, vision, and life insurance plans.
For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing
Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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