Scientist, Viral Vector Downstream Process Development

Eurofins • Boston, MA

2d

About The Position

We are seeking a highly skilled, passionate, and motivated scientist to join our Downstream Process Development team. This role will support downstream unit operations and pilot-scale manufacturing campaigns. The ideal candidate will have experience with AAV purification techniques with skills in data analysis and reporting data. The successful candidate will have a desire to succeed at the highest level to develop gene therapies for patients.

Requirements

• B.S. in life sciences with 4-6 years of industry experience or M.S. in life sciences with 2-3 years of industry experience in downstream bioprocessing.
• Previous experience in downstream unit operations (chromatography, filtration, centrifugation).
• Hands-on experience with chromatography techniques including affinity chromatography and IEX.
• Demonstrate a good understanding of tangential flow filtration (TFF) techniques.
• Experience with AAV, lentivirus, or other viral vector purification.
• Knowledge of small and pilot scale process development.
• Demonstrate critical thinking, be self-motivated, accountable, detail-oriented, have excellent organization and communication skills, and demonstrate the ability to work both independently and as a member of a team.
• Ability to work effectively with minimal supervision after initial training.
• Ability to troubleshoot and interpret experimental results and effectively summarize and present conclusions.
• Ability to work in a laboratory environment and handle occasional light to moderate lifting (up to ~50 lbs).

Nice To Haves

• Basic knowledge of analytical techniques for protein/viral vector characterization.
• Knowledge of aseptic techniques and cell culture.
• Familiarity with Unicorn software.
• Familiarity with statistical analysis software (JMP, Minitab).
• Exposure to process automation and single-use technologies.
• Strong desire to learn new techniques and a willingness to provide upstream cross-training support.

Responsibilities

• Downstream Process Development & Optimization (greater than 50% effort):
• Execute and troubleshoot downstream purification unit operations including affinity chromatography, tangential flow filtration (TFF), ion exchange chromatography, and ultracentrifugation.
• Perform buffer preparation, sample collection, and in-process testing.
• Maintain detailed laboratory notebooks and generate technical reports summarizing experimental findings.
• Pilot-Scale Manufacturing Support (less than 50% effort):
• Assist in pilot-scale manufacturing campaigns.
• Execute batch records with high attention to detail.
• Perform equipment setup, cleaning, and troubleshooting for pilot-scale unit operations.

Benefits

• Excellent full-time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Yearly goal-based bonus & eligibility for merit-based increases

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level