Bristol-Myers Squibb-posted 3 months ago
$123,670 - $149,855/Yr
Full-time • Mid Level
Hybrid • Princeton, NJ
Chemical Manufacturing

The successful scientist will work with colleagues throughout BMS to establish assays using immunohistochemistry, multiplex staining/imaging, in situ nucleic acid hybridization, and digital pathology. The scientist will be directly responsible for the design, development, execution, and analysis of discovery and translational tissue-based biomarker assays to interrogate target prevalence, target engagement, mechanisms of action, pharmacokinetics, pharmacodynamics, and prediction of treatment response. The position entails working on projects independently and in multi-disciplinary teams consisting of pathologists, lab scientists, data scientists, and clinical biomarker scientists. The IHC scientist will develop tissue-based assays for internal or external use with accountability for assays transferred to partner labs and contract research organizations (CROs). The scientist will also be responsible for working independently and with digital pathology colleagues to build and assess image analysis algorithms and workflows. The successful scientist must have strong technical experience in IHC assay development using several platforms and techniques and a working knowledge of histology/morphology/pathology interpretation relevant to assay development. The scientist must show strong communication and organizational skills, the ability to work collaboratively with other team members, adaptability to regulated work environments, and the flexibility to accommodate changing business needs.

  • Responsibility for all aspects of assay development including intake, research, planning, development, coordination, execution, risk communication/management, updates and transfer of assays including chromogenic immunohistochemistry (IHC), in-situ nucleic acid hybridization, multiplexed immunofluorescence (mIF) and digital pathology.
  • Design, organization, and execution of assay development workflow strategies (feasibility, verification, and validation), with appropriate knowledge and use of controls and test tissues.
  • Maintain technical proficiency across several IHC, mIF, histology and digital scanner technologies.
  • Coordinate with pharmacology teams to advise on preclinical models and study design parameters.
  • Responsible for working on multiple development projects simultaneously with appropriate project prioritization while also participating in lab management and other lab initiatives.
  • Review and scoring of stained slides with the engagement of pathologist oversight and review as needed.
  • Maintain workplace and lab compliant processes, documentation, and communication.
  • A bachelor's degree in biological sciences or related field with minimum 5+ years industry experience.
  • Prior experience working in the fields of oncology and/or immuno-oncology.
  • Prior experience with discovery programs and exploratory assay development is desired.
  • Prior experience performing antibody conjugations is a plus.
  • Experience in monoplex and multiplex IHC assay development (chromogenic and fluorescence) with comprehension of the underlying scientific principles.
  • Experience with automated IHC platforms is required.
  • A working knowledge of histology/morphology/pathology interpretation relevant to assay development.
  • Ability to evaluate and onboard new technologies related to tissue-based biomarker development.
  • The ability to thrive and self-motivate in an interdisciplinary workplace.
  • The ability to clearly communicate (verbal and written) scientific objectives, logical experimental design and the analysis and interpretation of data.
  • Prior experience working in a regulated laboratory setting (CAP/CLIA or other GCP environment) is a plus but not necessary.
  • Experience with digital scanning, image management systems (IMS), and digital image analysis platforms (HALO, Visiopharm) for H&E, immunohistochemical and multiplexed fluorescence images.
  • Experience with in-situ nucleic acid hybridization (RNA/DNA) studies on slide-based tissue samples.
  • Experience with formalin-fixed paraffin-embedded workflows is required.
  • Medical, pharmacy, dental and vision care.
  • Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
  • Financial well-being resources and a 401(K).
  • Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
  • Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
  • Parental, caregiver, bereavement, and military leave.
  • Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
  • Other perks like tuition reimbursement and a recognition program.
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