Scientist, Translational Inflammation

Gilead Sciences, Inc. • Foster City, CA

68d

About The Position

Gilead Sciences (Foster City, CA) is seeking a talented and highly motivated Translational Scientist to join our Inflammation group and contribute to translational research in fibrotic and inflammation diseases such as IPF, IBD, RA, and NASH. Our collaborative and interdisciplinary research team utilizes state-of-the-art technologies and innovative methodologies to advance medicines into the clinic. The successful candidate is expected to be lab-based and to contribute to the discovery, research, development and implantation of novel biomarkers to support clinical advancement of therapeutic agents in the disease areas.

Gilead Sciences is a world leader in antiviral research having developed small molecule compounds that have revolutionized the treatment of HIV, HCV, and HBV. Over the last 5 years, Gilead has significantly broadened its scope to encompass unmet medical needs in inflammatory and chronic fibrotic diseases.

Requirements

• Applicants must have a PhD or equivalent degree and at least 3 years of relevant post-graduate independent research or drug development experience in immunology, fibrotic and autoimmune diseases. Experience and knowledge in human fibrotic and inflammatory diseases, immunology research is preferred. The candidate must demonstrate top expertise in previous research areas, critical analytical skills, experimental design and execution, and ability to lead independent hypothesis-driven biological research, as exemplified by high quality publications. Strong communication skills required. Working knowledge of R/Python/SQL for assay QC and data review is preferred.
• PhD or equivalent degree and at least 3 years of relevant post-graduate independent research or drug development experience in immunology, fibrotic and autoimmune diseases OR 11+ years of experience with BS degree in related scientific discipline OR 9+ years of experience with MS degree in related scientific discipline.

Responsibilities

• Design and execute human‑relevant experiments in primary blood/tissue (gut, liver, skin, lung, synovium); perform responder vs non‑responder comparisons, perturbation studies, and pathway/target validation.
• High‑dimensional profiling: plan/execute high‑parameter flow or mass cytometry (≥18‑color), receptor occupancy and phospho‑flow; single‑cell (scRNA‑seq/ATAC) and spatial transcriptomics/proteomics; multiplex IF/IHC and quantitative pathology.
• Endotype & biomarker strategy: define disease‑agnostic PD/RO and endotype markers; qualify/validate fit‑for‑purpose assays (ELISA/MSD, qPCR/ddPCR, ligand‑binding, RO/TE) and transfer to internal labs/CROs under GCLP.
• Sample strategy & operations: contribute to protocol/IB biomarker sections; specify pre‑analytical handling, chain‑of‑custody and kitting; support CRO selection/oversight; ensure data integrity and timely delivery.
• Data integration & interpretation: partner with Biostats and Bioinformatics teams on analysis plans; integrate multi‑omic/imaging and clinical data; craft succinct go/no‑go narratives for governance.
• Influence without authority: coordinate across functions; document SOPs; contribute to safety/quality culture; mentor peers and have a growth mindset.
• Lead reverse translation workstreams: interrogate clinical/real‑world datasets with Clinical, Biostats, and Bioinformatics; generate mechanistic hypotheses for response/non‑response.
• Works independently and determines methods and techniques on new or difficult assignments.
• May design new experiments to support development of drug substances and drug products or techniques to test such substances.
• Works on complex problems where analysis of situations or data requires comprehensive evaluation of many factors.
• Maintains high level of expertise through familiarity with scientific literature and applies appropriately to projects.

Benefits

• This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees