Scientist - Tech Transfer

Twist BiosciencePortland, OR
Onsite

About The Position

We are seeking a Scientist to join our Tech Transfer team, focused on advancing and scaling synthetic biology workflows across DNA-based and mammalian cell culture systems. This role sits at the interface of R&D and production, where you will drive the successful transfer of new products and processes into high-throughput manufacturing environments. You will play a key role in developing, optimizing, and troubleshooting workflows spanning molecular biology and mammalian cell culture systems, ensuring processes are robust, scalable, and production-ready. This includes hands-on experimental work, cross-functional collaboration, and enabling operational teams through training, technical guidance, and documentation. This is a highly collaborative role partnering with teams across operations, automation engineering, and bioinformatics to translate innovation into reliable production processes. A key component of this work will be designing processes with automation in mind, enabling deployment across a diverse suite of liquid handling platforms to support scalable and standardized manufacturing. We are looking for someone who combines strong experimental rigor with practical problem-solving, and who is equally comfortable working at the bench and thinking strategically about process improvement. Experience across both DNA technologies (e.g., NGS, cloning) and mammalian cell culture/protein expression systems is highly valued. If you enjoy working in a fast-paced, multidisciplinary environment where you can directly impact how products are built and delivered at scale, this role offers broad exposure to cutting-edge synthetic biology platforms and technologies.

Requirements

  • PhD in Molecular Biology, Biochemistry, or related field; or Master’s with 2–5+ years of industry experience; or Bachelor’s with 5+ years of relevant experience
  • Strong foundation in molecular biology techniques, including DNA/RNA purification, PCR/qPCR, and molecular cloning
  • Hands-on experience developing and optimizing mammalian cell culture systems for protein expression (e.g., HEK, CHO)
  • Experience designing expression constructs and optimizing systems for yield, solubility, and activity across host platforms
  • Proven ability to develop and optimize upstream and downstream workflows, including transfection and protein purification strategies
  • Demonstrated experience in experimental design, data analysis, troubleshooting, and method development in complex biological systems
  • Strong attention to detail and ability to translate experimental outcomes into scalable process improvements
  • Solid scientific judgment and ability to independently drive technical decisions

Nice To Haves

  • Experience with next-generation sequencing (NGS) workflows, library preparation, and/or data analysis
  • Familiarity with high-throughput workflows and laboratory automation systems (e.g., liquid handlers)
  • Programming or data analysis experience (e.g., Python, SQL, JSON) for handling large datasets
  • Proven ability to manage multiple priorities in a fast-paced environment
  • Strong collaboration and communication skills, with experience working across multidisciplinary teams
  • Experience mentoring, training, or onboarding team members
  • Demonstrated problem-solving skills and a proactive, solution-oriented mindset
  • Self-motivated with a commitment to continuous learning and staying current with scientific advancements

Responsibilities

  • Design and execute experiments to develop, optimize, and scale production workflows for synthetic biology products, including DNA and mammalian cell-based protein expression systems
  • Drive process improvements by analyzing complex datasets and translating findings into actionable changes across workflows
  • Lead technical transfer of new products and processes into production, ensuring robustness, reproducibility, and scalability
  • Author and maintain technical documentation, including SOPs, validation protocols, and training materials to support manufacturing teams
  • Act as a technical subject matter expert, representing R&D/PD in cross-functional meetings and contributing to project strategy and decision-making
  • Collaborate cross-functionally with operations, automation, and bioinformatics teams to troubleshoot issues and implement solutions
  • Apply scientific literature and domain expertise to inform experimental design, process development, and strategic direction
  • Maintain clear and accurate documentation of experimental work and results using electronic lab notebooks
  • Mentor and train team members and operators on newly developed processes and workflows

Benefits

  • In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package.

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What This Job Offers

Job Type

Full-time

Career Level

Mid Level

Education Level

Ph.D. or professional degree

Number of Employees

251-500 employees

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