Scientist, Syntein™ Purification & Physicochemical Properties

Flagship Pioneering, Inc. • Boston, MA

182d

About The Position

As a key member of Abiologics’ chemistry team, you’ll play a leading role in developing new methods to analyze and purify our Synteins™ drug candidates. You will work closely with medicinal and peptide chemists to characterize and measure physicochemical properties of our Synteins. You’ll participate in a large machine learning platform initiative aimed at determining optimal physicochemical property parameters for our new drug modality and urgently progressing Synteins toward the clinic.

Requirements

• PhD in Chemistry, Chemical Engineering, or Biochemistry with 0-2 years or B.S or M.S in Chemistry or related field with 5+ years of industry experience in a laboratory setting.
• Excellent in troubleshooting chromatographical (HPLC) and/or mass spectrometry (MS) issues.
• Experience using Agilent and/or Shimadzu is a plus.
• Experience with solubility assessment and measurement of compound properties a plus.
• Capacity to execute tasks independently to achieve company goals on an established timeline.
• Superb multi-tasking, creativity, adaptability to fast-paced changing environment, and teamwork skills.
• Knowledge of, and appreciation for, laboratory safety procedures.
• Self-motivated and enthusiasm to work in a dynamic research environment.
• Able to work on-site and attend in-person meetings.

Responsibilities

• Rapid development of analytical and preparative methods to isolate our Synteins with high purity standard.
• Measure physicochemical properties such solubility, stability, and concentration with UV spectroscopy and high-resolution mass spectrometry techniques.
• Characterization of secondary structure with a variety of analytic techniques.
• Integrate, analyze, and report results to guide new compound design in our therapeutic programs.
• Work closely with our computational scientists to generate properties-based machine learning models for our Synteins optimization.
• Build additional capabilities to ensure high-throughput purification and measurement of physicochemical properties of Synteins.
• Develop analytical methods needed during optimization of synthesis or formulation of Synteins.

What This Job Offers

• Career Level: Entry Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 251-500 employees