Staff Scientist - Antibody Platform Development (South San Francisco, CA)

Twist Bioscience•South San Francisco, CA

3d•$127,000 - $180,000

About The Position

Twist is searching for a curious, thoughtful, and driven RnD scientist with excellent lab hands to enhance our antibody development platform development efforts. You will use your deep scientific experience and knowledge in various antibody and antibody-like modalities to as well as expertise in molecular biology, cell culture, automation, and analytical techniques to create and improve platform technologies for antibody discovery, development and transition to the clinic. We are looking for people who have deep technical knowledge and a strong drive to get things done. Job title and compensation will be determined based on several factors, including but not limited to the candidate's years of experience, individual skills, knowledge, and abilities.

Requirements

Deep hands-on experience designing, expressing, and optimizing monoclonal antibodies, with demonstrated understanding of Fc structure–function relationships (effector function, stability, manufacturability).
Proven experience with bispecific antibody architectures, including but not limited to: Knob-in-hole, CrossMab, common light chain, or similar
Chain pairing control, mispairing mitigation, and associated analytics
Extensive experience generating and optimizing stable mammalian cell lines (CHO preferred): Vector design, promoter/selection strategies
Clone screening, productivity optimization, and stability assessment
Strong understanding of transient vs stable expression tradeoffs and when to deploy each during platform development.
Experience improving expression yields and product quality through sequence, vector, and host engineering.
Demonstrated ability to build, improve, and standardize antibody generation workflows.
Experience developing high-throughput or semi-automated workflows for expression, purification, and screening.
Strong understanding of platform robustness, reproducibility, and cost drivers.
Hands-on experience with antibody characterization methods, including but not limited to: SEC, CE-SDS
Binding kinetics (BLI or SPR)
Basic biophysical profiling (DSF, DLS)
Mass spectrometry
Strong mechanistic understanding of antibody biology, structure, and expression bottlenecks
Experience designing platforms that support multiple antibody modalities (mAbs, bispecifics, Fc-engineered variants)
A track record of successful and creative method development
Advanced degree in Cell Biology, Biochemistry, Chemical Engineering, or a closely-related field
Scientist Requires a PhD and 0-2 years of previous professional experience; or a master's degree and 3-5 years of work experience
Sr Scientist Requires a Ph.D. and 3-5 years of professional experience (postdoc may count); or a master's degree and 7+ years of work experience
Staff Scientist Requires a Ph.D. and 6-10 years of professional experience (postdoc may count); or a master's degree and 10+ years of work experience

Nice To Haves

Familiarity with Python or equivalent programming languages is a plus
Experience with liquid-handling systems and automation is a plus

Responsibilities

Develop antibody production, purification and analytical workflows at various scales and throughput, across various formats (single-chain, IgG, multi-specific, Fc-Fusion, etc).
Optimize all aspects of the end-to-end antibody development workflow including but not limited to: construct design, protein expression (transient and stable), purification, and analytics
Independently design and execute experiments, and analyze experimental data
As appropriate, build and lead a team to achieve technical goals
Move projects forward efficiently / manage time and resources effectively / prioritize tasks in accordance with the company’s goals
Document and communicate results clearly and succinctly
Be helpful / collaborative / proactive
Stay up to date with new developments, companies, and technologies
Be the ultimate subject matter expert, and understand all aspects of your work as profoundly as possible, including details that are adjacent to your projects

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