Scientist/Sr. Scientist, Functional Genomics

General Proximity•San Francisco, CA

26d

About The Position

We are seeking an experienced functional genomics expert to be a founding member of our Platform/Bioengineering Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics. Your responsibilities will include: designing and building pooled and arrayed CRISPR or ORFeome libraries for high-throughput screening, conducting functional genomics and phenotypic screens using lentiviral systems, FACS, and reporter-based assays, analyzing next-generation sequencing data from pooled screens, generating and maintaining stable or inducible cell lines for screening and validation studies, optimizing viral vector production, transduction, and titration protocols, and collaborating across disciplines to refine screening assays, troubleshoot workflows, and interpret results.

Requirements

PhD in Molecular Biology, Genetics, Biochemistry, or related field.
Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
Deep understanding of small-molecule drug discovery and its relationship to human disease.
Strong problem-solving skills and the ability to work independently as well as part of a team.
Top-notch written and oral communication skills.
Genome editing and engineering, particularly CRISPR/Cas systems, vector design, and cell line engineering
Developing and executing pooled phenotypic and functional genomics screening platforms, from library design to hit validation
Designing and building pooled and arrayed CRISPR or ORFeome libraries for high-throughput screening
Molecular cloning (Gibson, Gateway, PCR) and automation tools for high-throughput assays
Next-generation sequencing (library prep through data analysis)
Data analysis, bioinformatics, and visualization (R, Python, MATLAB)
Multiple gene editing techniques (knockout, HDR knock-in, prime or base editing)
Gene editing in hard to culture cells and Lonza nucleofection

Nice To Haves

Familiarity with PROTACs, IPM, or induced-proximity drug discovery
Expertise with protein–protein interaction assays (BRET, BioID/APEX, AlphaScreen)
Experience managing others, especially synthetic chemistry CRO teams
Prior experience on teams that have successfully advanced research to the clinic

Responsibilities

Designing and building pooled and arrayed CRISPR or ORFeome libraries for high-throughput screening
Conducting functional genomics and phenotypic screens using lentiviral systems, FACS, and reporter-based assays
Analyzing next-generation sequencing data from pooled screens
Generating and maintaining stable or inducible cell lines for screening and validation studies
Optimizing viral vector production, transduction, and titration protocols
Collaborating across disciplines to refine screening assays, troubleshoot workflows, and interpret results.

Benefits

Strong equity incentives.
Top tier medical, dental, and vision coverage + One Medical membership.
401(k) retirement plans.
Education and health/fitness incentive programs.
Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
Reading budget! We will buy you books.
Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

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