Scientist - Renal

Eli Lilly and Company • Indianapolis, IN

3d

About The Position

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Renal Biologist (R2-R4) At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. The Diabetes, Obesity and Complications Therapeutic Area (DOCTA) of Eli Lilly and Company, focuses on the discovery of biologic, small molecule and genetic therapeutics for the treatment of diabetes, obesity and associated complications. We are seeking a highly motivated lab-based scientist to join our Indianapolis Diabetes/Obesity research team that is focused on developing innovative therapeutics to treat cardiovascular and renal complications associated with obesity and diabetes. The ideal candidate will have a strong background in cell and molecular biology techniques, with a preferred focus on renal cell systems and endpoints, coupled with extensive experience in in vitro and in vivo pharmacology.

Requirements

• Bachelor’s degree with 4-5 years industry experience, or Master's degree with 0-3 years industry experience in Pharmacology, Cell Biology, Molecular Biology, or a related field.
• Experience in in vivo pharmacology, including model development and characterization, proficiency in animal handling techniques, different dosing techniques/routes (PO, IV, IP, Subcutaneous), tissue extraction and preparation for downstream analysis
• Proficiency in cell and molecular biology techniques, including next generation western blot techniques, RT-qPCR, lentiviral overexpression systems, CRISPR/Cas9 gRNA design and experimentation, primary cell isolation and culture techniques,
• Demonstrated ability to work effectively in a team environment, collaborate with colleagues on research projects and deploy creative analytical and problem-solving skills when necessary.

Nice To Haves

• Experience with renal cell systems and endpoints preferred but not required.

Responsibilities

• Conduct in vitro and in vivo pharmacology studies to evaluate the efficacy and safety of therapeutic candidates.
• Utilize cell and molecular biology techniques, including cell culture, transfection, PCR, Western blotting, and immunohistochemistry.
• Design and execute experiments involving renal cell systems, including primary cell cultures and cell lines, including utilization of CRISPR/Cas9 systems to modify gene expression in cell lines.
• Execute experiments utilizing different classes of drug modalities including small molecules, biologics and oligonucleotides, among others.
• Execute experiments and analyze data from in vivo models of renal disease including but not limited to endpoints such as glomerular filtration rate, gene and protein expression from tissue, urine and plasma.
• Communicate results clearly and effectively with team members and the scientific community through reports, presentations or publications and collaborate with cross-functional teams to advance drug discovery and development projects.

Benefits

• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
• In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees