Scientist, Rare Metabolic and Neurological Diseases

Sanofi•Cambridge, MA

14h•Hybrid

About The Position

We are seeking a highly motivated and skilled Scientist with deep expertise in rare metabolic, and neurological diseases. The ideal candidate will have a deep expertise in part of our target disease areas, including neurodevelopmental diseases (Fragile X, Dravet, Angelman, SYNGAP1, Rett, among others), primary mitochondrial diseases, and leukodystrophies. They will bring robust hands-on experience in in vivo and in vitro target identification and validation strategies, disease modeling, combined with a strong foundation in disease biology and pathophysiology. This role will spearhead efforts to discover and validate novel therapeutic targets and strategies, leveraging both experimental and analytical approaches. They will collaborate closely with cross-functional teams to translate biological insights into therapeutic programs, contributing to the strategic expansion of our portfolio. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions. About Sanofi: We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Requirements

PhD in a biological field; entry-level is acceptable with demonstrated in vivo experience working with rodents.
Master’s degree in biological field, with 3+ years of experience in an academic or biopharmaceutical setting, OR Bachelor’s degree in a biological field and 6+ years of research experience in an academic or biopharmaceutical setting.
Extensive hands-on experience working with rodents, including performing in vivo studies for pharmacology, disease modeling, or therapeutics development; proficiency in dosing techniques (IV, IP, PO) and dissections is required.
Understanding of disease biology in metabolic, mitochondrial, OR neurodevelopmental disorders.
Demonstrated ability to produce high-quality scientific documentation, including experimental protocols, SOPs, technical reports, presentations, and animal use protocols in compliance with IACUC requirements.
Proven track record of meaningful contributions to research programs, evidenced by scientific publications and/or presentations.
Familiarity with target discovery, preclinical validation, and early drug development workflows.
Ability to work independently and collaboratively within cross-functional, matrixed teams.
Highly adaptable, with strong multitasking skills and ability to manage shifting priorities and timelines.
Clear written and verbal communication skills, able to convey complex concepts to diverse audiences.
Outstanding organizational skills, attention to detail, and commitment to scientific rigor.

Nice To Haves

Preferred fields include Neuroscience, Metabolic disease, mitochondrial biology, and/or RNA biology.
Experience with behavioral assessments, stereotaxic surgeries, and CSF extraction is desirable.
Proficiency with iPSC-derived mono- and co-cultures is desirable.

Responsibilities

Support pipeline programs and new program initiation by applying expertise in disease mechanisms, translational biology, and model development.
Design and conduct mechanism-of-action, PK/PD, and proof-of-concept studies using animal models and in vitro assays.
Contribute to interdisciplinary research programs across internal teams and external partnerships, with opportunities to grow into functional lead and project lead roles.
Prepare high-quality analyses, documentation, and presentations to support project milestones, publications, patent filings, and regulatory submissions (IND/CTA).
Present findings and progress in internal meetings and external scientific venues.

Benefits

Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
Help improve the lives of millions of people globally by making drug development quicker and more effective.
Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

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