Scientist, Protein Biochemistry

GSK•Cambridge, MA

About The Position

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life. We’re looking for a passionate and highly motivated protein biochemist to join the structural biology team to apply the full range of structural biology, protein biochemistry, and computations tools to design vaccines as well as to antibodies, biologics, and small molecules. As a crucial member of our team, you will be at the center of our structural biology and biophysical characterization operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for construct design, purification and assessment of protein behavior using biophysical methodologies. With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor within the department and across therapeutic areas. The position will require active collaboration with diverse teams to work together and address key challenges.

Requirements

PhD degree in life sciences with 0+ years of experience in a related biotechnology field or Masters degree with at least 2 years of experience in a related biotechnology field.
Minimum of one year of hands-on experience on protein purification and characterization in the research lab or biological manufacturing facility.
Minimum of one year of experience purifying protein from mammalian cell culture including HEK293 and/or CHO cell lines.
Minimum of one year of experience in the operation and maintenance of AKTA systems.
Minimum of one year of experience performing common lab techniques including liquid chromatography (SEC, ion-exchange, affinity columns), SDS-PAGE, western blot.
Excellent oral and written communication skills with a fluency in English.

Nice To Haves

Demonstrated ability to successfully purify proteins on interest using diverse separation techniques including IEX, affinity, HIC, multimodal, and SEC.
Demonstrated ability to characterize purified material using biophysical techniques including HPLC, nanoDSF, BLI, SPR and/or mass photometry.
Experience in molecular biology techniques, cloning, PCR, Gel electrophoresis.
Experience with the purification of proteins from additional protein expression systems including bacterial, insect and/or yeast.
Familiarity with buffer exchange, TFF, and related process techniques.
Excellent problem-solving skills and the ability to troubleshoot technical issues.
Demonstrated ability to work independently and as part of a diverse team.
Demonstrated ability to manage competing priorities and stakeholders.
Strong communication skills.
Able to efficiently manage uncertainty, changes in priority and timeline restrictions.

Responsibilities

Purify and perform biochemical and biophysical experiments to characterize the purified proteins and deliver structural reagents.
Contribute to the design of new constructs and mutants based on results from biophysical and structural analysis.
Work closely with the protein production and structural biology teams to select the best constructs and conditions for structural assessment.
Document your work and ensure appropriate quality control experiments are carried out to support intellectual property and reagent reuse by other groups.
Present results and progress updates at team meetings.

Benefits

Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role.

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