Scientist, Product and Analytical Sciences, Cell Therapy Development Operations

Celgene • Warren, NJ

43d • Onsite

About The Position

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . Position Summary Working within Cell Therapy Development Organization (CTDO) the individual will become part of the Product and Analytical Sciences group, part of CTAD (Cell Therapy Analytical Development function) based in Warren, NJ. The incumbent will contribute to the IND and BLA clinical laboratory component of early and late-stage studies contributing to biological product knowledge and analytical characterization of CAR T pipeline assets. The incumbent will work with other scientists and teach junior technical staff as needed to complete pipeline development projects. Key responsibilities of this role are to lead from the bench for the laboratory support of asset programs through design and experiment execution to support mechanism of action-based studies, characterization of cellular materials, fit-for-purpose assay development, early qualification studies and investigations support. Duties/Responsibilities Under general direction, the incumbent will design/co-design and execute experiments and testing to support early and late-stage BMS cell therapy product development. Lead from the bench with assay development under strict timelines as well as routine testing requests of CAR T products as well as analysis and interpretation of characterization data to support product clinical development for Regulatory filling purposes, manufacturing investigations, life cycle management process support, and translational team requests. Lead or contribute to qualification of characterization methods to support CAR-T product CMC data packages Contribute to acquisition of deeper understanding of product biology, and support mechanism of action studies for CAR T cell programs. Present internal scientific findings and relevant literature observations within the functional area, as needed. Contribute to sample management as needed and the basic maintenance and troubleshooting of instrumentation, as needed. Individual will contribute to process/technology improvements and to scientific/technical data review and writing (e.g., regulatory documents, protocols, etc.) as required. Ensure proper operation and perform routine maintenance of laboratory equipment. Maintain a safe workplace in accordance with company and OSHA policies/procedures.

Requirements

• B.S. or M.S. in Immunology, Cell/Molecular Biology, Biomedical Engineering or related discipline with 5+ academic and/or industrial experience for Scientist.
• Ph.D. in Immunology, Cell/Molecular Biology, Biomedical Engineering or related discipline with 2+ years of academic and/or industrial experience.
• Strong desire to work within a team structure and to develop, mentor and coach team members leading to their success, engagement and growth are required.
• The individual will work under technical supervision, perform technical, strategic and operational tasks independently and lead complex and functional general activities.
• Extensive experience in mammalian cell culture techniques, including isolation of immune cell subsets, maintenance and expansion of primary cells and cell lines is required.
• Advanced knowledge of basic techniques in immunology, cell biology and molecular biology is required.
• Good verbal and written communication skills.
• Willingness to work in a regulated industrial environment.

Nice To Haves

• Abstract/manuscript publications preferred for a PhD.
• Experience with FACS, immunofluorescence-based assays, ELISA, PCR, cytokine and chemokine detection, cell-based bioassays is highly desired.
• Experience with analytical method development for a variety of cell-based bioassays, binding assays and/or residual impurities assays is highly desired.
• High motivation and drive to acquire new skills and knowledge is desired

Responsibilities

• Design/co-design and execute experiments and testing to support early and late-stage BMS cell therapy product development.
• Lead from the bench with assay development under strict timelines as well as routine testing requests of CAR T products as well as analysis and interpretation of characterization data to support product clinical development for Regulatory filling purposes, manufacturing investigations, life cycle management process support, and translational team requests.
• Lead or contribute to qualification of characterization methods to support CAR-T product CMC data packages
• Contribute to acquisition of deeper understanding of product biology, and support mechanism of action studies for CAR T cell programs.
• Present internal scientific findings and relevant literature observations within the functional area, as needed.
• Contribute to sample management as needed and the basic maintenance and troubleshooting of instrumentation, as needed.
• Individual will contribute to process/technology improvements and to scientific/technical data review and writing (e.g., regulatory documents, protocols, etc.) as required.
• Ensure proper operation and perform routine maintenance of laboratory equipment.
• Maintain a safe workplace in accordance with company and OSHA policies/procedures.

Benefits

• Medical, pharmacy, dental and vision care.
• Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
• Financial well-being resources and a 401(K).
• Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
• Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
• Parental, caregiver, bereavement, and military leave.
• Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
• Other perks like tuition reimbursement and a recognition program.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees