Scientist, Process Development

Alnylam Pharmaceuticals • Cambridge, KS

268d

About The Position

The Scientist, Process Development will be responsible for leading drug substance process development projects for early-stage programs, with a focus on optimizing oligonucleotide process and developing process for oligonucleotides with novel chemical modifications. The role involves overseeing development projects, supporting nGMP drug substance manufacturing, and collaborating with various cross-functional teams within the organization. The ideal candidate must have strong problem-solving skills, extensive knowledge of oligonucleotide chemistry, and proven experience in oligonucleotide process development. This position is onsite and will be primarily located at our Cambridge, MA location.

Requirements

• PhD in Organic/Medicinal Chemistry, Chemical Engineering with 1-3 years post degree experience, preferably in an industrial setting.
• Strong experience and knowledge in oligonucleotide synthesis, purification, and characterization.
• Hands-on experience in automated solid-phase DNA synthesizer, demonstrated strong operational execution and problem-solving skills.
• Experience in analytical techniques (pH, HPLC, LC-MS etc.), or related hands-on experience, is preferred.
• Ability to work within cross-functional teams and work as a team player.
• Ability to lead projects and demonstrate strong oral & written communication, and presentation skills.
• Strong experience in record-keeping and excellent laboratory documentation practice are required.
• Strong commitment to preserving a high laboratory and scientific standard; maintaining a safe, clean, and orderly laboratory work environment.

Responsibilities

• Leading or being actively involved in process development projects including oligonucleotide synthesis activities, process development, optimization and scale-up.
• Working closely with process sciences and cross-functional teams within the organization.
• In-process analytical method development and utilization.
• Communicate relevant information and results to CMC development department as well as other key stakeholders throughout the organization.
• Creation, review, and usage of SOPs and batch records employed for the in-house non-GMP oligonucleotide manufacturing.
• Technical protocols and reports authoring and reviewing.

What This Job Offers

• Career Level: Entry Level
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree