Scientist, Potency and Functional Characterization

Bristol Myers Squibb•Seattle, WA

About The Position

We are seeking a highly motivated professional to join the Cell Therapy Analytical Development team, specializing in cell line engineering and potency method development for viral vector applications. The ideal candidate will contribute to the optimization and qualification of cell-based viral vector transduction assays measured by flow cytometry and luminescent reporter genes. This position demands a strong foundation in cell culture, keen attention to detail, and enthusiasm for solving scientific challenges in a fast-paced, collaborative environment. Successful candidates will demonstrate competency in these areas and contribute to breakthrough developments in cell therapy.

Requirements

Ph.D. in Immunology, Cell Biology, Bioengineering, or a related field with 0–3 years of industry experience; or an MS/BS with 5+ years of relevant laboratory experience.
Proficiency in cell culture, viral vector transduction, cell line engineering, flow cytometry, and relevant analytical assays (e.g., ELISA).
Strong organizational, documentation, and communication skills.
Ability to thrive in a collaborative, fast-paced, and dynamic environment.

Nice To Haves

Experience with JMP and SoftmaxPro softwares is preferred.
Experience with vector construct design is highly desirable.
Background in DNA/RNA transfection, viral vector transduction, and potency release method development is preferred.

Responsibilities

Generate monoclonal cell lines and establish cell banks by transducing cells with viral vectors, expanding the cultures, isolating monoclonal populations through cell sorting, banking the validated cell lines, and performing functional qualification using lot-release potency and flow cytometry assays.
Design and execute laboratory experiments to optimize DNA/RNA transfection, viral transduction, flow cytometry and plate based potency reporter gene assay parameters and procedures to meet the pre-defined analytical target profile.
Contribute to method qualification and transfer activities based on ICH/USP guidelines.
Analyze complex data sets, perform data trending and visualization, and maintain detailed experimental records in ELN for reproducibility and quality assurance.
Document cell line generation processes and experimental findings, contributing to SOPs, technical reports, and regulatory filings to ensure compliance and support innovation.
Cultivate and maintain cell lines and primary cells essential for innovative assay development.
Manage lab operations by overseeing inventories, scheduling equipment maintenance, and implementing process improvements for efficiency and productivity.

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

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