Scientist, Pharmacokinetics

MSD • South San Francisco, CA

4d • Hybrid

About The Position

This position will contribute to our Company's drug discovery and development efforts in the Drug Metabolism and Pharmacokinetics (DMPK) Group within the Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) organization at our Research & Development Division in South San Francisco, CA. Candidate will primarily perform lab-based activities and be responsible for generating in vitro DMPK data to guide lead candidate optimization and development efforts. Candidate will have the opportunity to work closely with scientists across the network. They will leverage novel tools and emerging technology to evolve our approach. Embedded in our Company's network, this role will facilitate the seamless transfer of protocols and data across platforms to advance our scientific strategy. Successful candidate will impact projects across therapeutic areas through their passion for generating high-quality data. The ideal candidate will exhibit strong laboratory skills, including the ability to independently execute the bioanalysis of in vitro and in vivo samples, and possess the capacity to contribute to implementing automation to streamline workflows. Candidate must have demonstrated leadership and accountability for setting standards for excellence to deliver high-quality results within established timelines, ability to work in a team environment, excellent written and verbal communication skills, and possess an innovative mindset to participate in identification of problems and opportunities to deliver solutions.

Requirements

• Bachelor’s degree (with 3 years) or Master's in analytical chemistry, biochemistry, biotechnology or related science field with relevant laboratory experience
• Strong background in analytical chemistry and/or biochemistry
• Hands-on experience with quantitative analysis using LC-MS or other analytical techniques
• Handling of enzymes, tissue preparations and biological fluids/matrices
• Experience with cell culture and the conduct of cell-based assays
• Experience maintaining laboratory notebooks and conducting data-fitting using commercially available software packages such as Excel, Graphpad Prism, TIBCO Spotfire, etc.
• Strong interpersonal, communication, problem solving, and collaborative attributes to deliver high-quality results in a fast-paced environment
• Autonomy, attention to detail, critical thinking, growth mindset

Nice To Haves

• Working knowledge of ADME-related assays, such as plasma protein binding, metabolic stability, reaction phenotyping, enzyme inhibition, metabolite identification, and associated analytical techniques
• Familiarity with troubleshooting LC-MS instrumentation
• Experience with robotics, assay automation, and operation of liquid handlers in support of high-throughput workflows
• Experience working at a research-driven pharmaceutical company or contract research organization

Benefits

• The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
• We offer a comprehensive package of benefits.
• Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days.
• More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees