Scientist or Senior Scientist, Cell Line Development

Bristol Myers Squibb•New Brunswick, NJ

2d•Onsite

About The Position

We are seeking an enthusiastic candidate to join Bristol Myers Squibb’s Cell Line Development team in New Brunswick, New Jersey. This group is part of the larger GUCLD (Global Upstream and Cell Line Development) organization, which primarily focuses on delivering high-quality cell lines and cell culture processes to advance clinical and commercial programs. This position involves fundamental responsibilities, including the development of expression vectors and mammalian cell lines for the production of monoclonal antibodies, bi-specific antibodies, and antibody-drug conjugates, and requires close collaboration across functions with upstream, downstream, analytical development, and R&D teams. The successful candidate will leverage expertise in protein folding, trafficking, and advanced cell engineering to drive innovation in mammalian cell line development for recombinant protein production. This role requires strong experimental skills, scientific leadership, and the ability to collaborate effectively in cross-functional teams within a fast-paced research environment. This position offers excellent opportunities for professional growth and career development in biologics process development.

Requirements

Ph.D. in Biological Sciences, Bioengineering, Chemical Engineering, or relevant disciplines, with 0-2 years of relevant experience or MS with 2-4 years relevant experience or BS with 5-7 years relevant experience.
Ph.D. in Biological Sciences, Bioengineering, Chemical Engineering, or relevant disciplines, with 2-4 years of relevant experience or MS with 4-6 years relevant experience or BS with 7-9 years relevant experience.
Hands-on experience in mammalian cell line development.
Familiarity with Western blotting, cell staining, and FACS sorting.
Strong molecular biology skills in vector design, plasmid construction, cloning, purification, and characterization.
Proficient in transcript quantification and genetic characterization, with hands-on experience in RNA-based technologies such as siRNA and miRNA.
In-depth knowledge of protein and antibody folding and trafficking in the cell.
Strong organizational skills and a proven ability to independently lead scientific projects from hypothesis generation through execution and conclusion.
Demonstrated ability to think critically and possess excellent problem-solving skills.
Excellent collaboration, oral, and written communication skills; demonstrated success working in cross-functional teams and contributing to shared goals in a fast-paced research environment.
Proven record of publication in peer-reviewed journals and presentations at conferences.

Nice To Haves

Experience with advanced cell engineering, omics, and synthetic biology is preferred.
Experience operating AMBR microbioreactors and automated liquid handling systems is a plus.

Responsibilities

Lead cell line development projects and perform key activities associated with production cell line development, including transfection, selection, single cell cloning, high-throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.
Design and optimize mammalian expression vectors and systems; perform transcript quantitation and genetic characterization as needed.
Serve as a subject matter expert to support cell line development in cross-functional CMC teams, as well as author and review regulatory filings for early and late-stage projects.
Evaluate and introduce innovative technologies to optimize therapeutic protein folding and production.
Generate hypotheses, plan and execute experiments, analyze data, and draw actionable conclusions.
Collaborate closely with upstream, downstream, and analytical development teams.
Present technical summaries to peers and upper management, as well as prepare technical writing for development reports and regulatory filing support.
Publish and/or present scientific findings at external conferences.

Benefits

Medical, pharmacy, dental and vision care.
Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
Financial well-being resources and a 401(K).
Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
Parental, caregiver, bereavement, and military leave.
Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
Other perks like tuition reimbursement and a recognition program.

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