Scientist, Oligonucleotide (PMO) Process Development

Avidity Biosciences Inc•San Diego, CA

15h•$145,000 - $160,000•Onsite

About The Position

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com [https://c212.net/c/link/?t=0&l=en&o=3867927-1&h=540455448&u=http%3A%2F%2Fwww.aviditybiosciences.com%2F&a=www.aviditybiosciences.com] and engage with us on LinkedIn [https://c212.net/c/link/?t=0&l=en&o=3867927-1&h=3458955515&u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D3849311-1%26h%3D1532752011%26u%3Dhttps%253A%252F%252Fc212.net%252Fc%252Flink%252F%253Ft%253D0%2526l%253Den%2526o%253D3824048-1%2526h%253D1295074681%2526u%253Dhttps%25253A%25252F%25252Fc212.net%25252Fc%25252Flink%25252F%25253Ft%25253D0%252526l%25253Den%252526o%25253D3758964-1%252526h%25253D1535717129%252526u%25253Dhttps%2525253A%2525252F%2525252Fc212.net%2525252Fc%2525252Flink%2525252F%2525253Ft%2525253D0%25252526l%2525253Den%25252526o%2525253D3701287-1%25252526h%2525253D2046811440%25252526u%2525253Dhttps%252525253A%252525252F%252525252Fc212.net%252525252Fc%252525252Flink%252525252F%252525253Ft%252525253D0%2525252526l%252525253Den%2525252526o%252525253D3640662-1%2525252526h%252525253D3325811211%2525252526u%252525253Dhttps%25252525253A%25252525252F%25252525252Fc212.net%25252525252Fc%25252525252Flink%25252525252F%25252525253Ft%25252525253D0%252525252526l%25252525253Den%252525252526o%25252525253D3245424-1%252525252526h%25252525253D2320056573%252525252526u%25252525253Dhttps%2525252525253A%2525252525252F%2525252525252Fwww.linkedin.com%2525252525252Fcompany%2525252525252Favidity-biosciences-llc%252525252526a%25252525253DLinkedIn%2525252526a%252525253DLinkedIn%25252526a%2525253DLinkedIn%252526a%25253DLinkedIn%2526a%253DLinkedIn%26a%3DLinkedIn&a=LinkedIn] and X. We are seeking a Scientist experienced in organic synthesis, route selection, and process optimization to join a team dedicated to the development of liquid-phase processes to manufacture phosphorodiamidate morpholino oligonucleotides. The ideal candidate will have an understanding of drug substance control strategy and process characterization workstreams. This is a hands-on position with responsibilities that require daily lab work, designing and performing organic transformation, as well as product purification and isolation in the lab. The lab experimentation is to be carried out with scale-down version of manufacturing footprint as well as in-situ analysis tools. The position will report to the Sr Director of Oligonucleotides development at Avidity and be a part of Avidity's growing CMC/Technical Operations team.

Requirements

PhD in Chemistry with at least 0-2 years of industrial experience or a Master’s degree in Chemistry with at least 10 years of experience.
Demonstrated experience in organic synthesis and process development.
Prior experience with various laboratory techniques including LC-MS/MS, HPLC, and NMR.
Proven ability to thrive and enable success in a cross-functional and collaborative environment.
Excellent communication and interpersonal skills and the ability to facilitate constructive, expedient problem-solving.
Ability to multi-task, manage conflict, and work in a fast-paced environment.

Responsibilities

Execute experiments enabling the determination of processing conditions for the manufacture of phosphorodiamidate morpholino oligonucleotides in liquid phase.
Assess various routes of synthesis to prepare phosphorodiamidates morpholino oligonucleotides, including via fragment assembly.
Determine data-based path forward to optimize and lock manufacturing processes.
Understand first principles of chromatography, UF/DF unit operation, and lyophilization and be able to carry out those unit operations in the laboratory.
Analyze in-process control and isolated product collected samples via chromatography, mass spectroscopy, and NMR techniques.
Perform critical review of manufacturing documentation.
Accurately document experiments in electronic laboratory notebooks and author technical summaries and study reports.
Present data and provide updates in team and CMC meetings.
Ensure work is conducted in compliance with applicable regulatory requirements (FDA, EMA, ICH), GMP principles (as applicable), and internal quality systems.
Collaborate cross-functionally with Analytical Development, Quality, and Project Management teams.
Contributes to the company's core values (agile, visionary, integrated, and diverse)

Benefits

The base salary range for this role is $145,000 to $160,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
Avidity offers competitive compensation and benefits, which includes the opportunity for annual bonus as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and four weeks of time off.

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