Scientist, Molecular Pathology Lab

Alnylam Pharmaceuticals • Cambridge, MA

2d • Onsite

About The Position

The Pathology team is seeking a Molecular Pathology Scientist. Experience performing and evaluating immunohistochemistry and/or in situ hybridization is essential. Interpretation of labeled specimens requires an understanding of anatomy and histology and an ability to identify specific cell populations in tissue sections. Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.
This position is onsite and will be primarily located in Cambridge, MA.

Requirements

• Bachelor’s degree or higher in life sciences field with 8+ years of laboratory experience.
• ASCP Histotechnician certification(s).
• Experience performing and evaluating immunohistochemistry and/or in situ hybridization is essential.
• Interpretation of labeled specimens requires an understanding of anatomy and histology and an ability to identify specific cell populations in tissue sections.
• Experience routinely demonstrating initiative that has a direct impact on the pathology labs operation, improvement and refinement.
• Ability to communicate and present complex scientific information to scientific and non- scientific audiences.
• Ability to make decisions autonomously and requires minimal guidance to perform job duties.
• Communicate openly and directly with laboratory group, departmental and cross-functional scientific groups, and management.
• Proven project management skill set, evidenced by history of successful project delivery and successful timelines completed.
• Strong analytical, problem solving, and decision-making skills.

Responsibilities

• Conduct antibody optimization for immunohistochemistry.
• Perform immunohistochemical and in-situ hybridization procedures to include multiomic staining protocols using the Leica BOND and/or Discovery ULTRA staining platform.
• Analyze and evaluate assays for sensitivity and specificity.
• Mount, label and distribute or scan prepared microscope slides to pathologists or to appropriate areas for interpretation.
• Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.
• Responsible for maintaining reagents, preventative maintenance procedures and troubleshooting for relevant equipment.
• Proficiency in tissue trimming/embedding and microtome/cryostat tissue sectioning.
• Maintain regulatory compliance and SOPs.
• Cross-functional collaboration with the research group and broadly with other departments throughout the company.
• Ensures compliance and alignment with all EH and S initiatives within the Molecular Pathology Laboratory.
• Operateswithin a quality management system and collaborates with quality assurance and regulatory team to improve laboratory processes, optimize methods, and develop quality analytics.
• Experience with online ordering of lab materials, reagents, as well as maintaining inventory of lab supplies.
• Ensure ELN (electronic lab notebooks) are kept up to date in a complete and consistent manner, following all legal requirements as well as keeping clear and complete record.
• Support validation of new assays and instruments for molecular histology.
• Maintain knowledge of scientific technological developments by reading the current literature and attending professional conferences to develop innovative concepts, which may lead to new assays, equipment requests, and/or procedures.
• Participate in planning and execution of Early Development (eDEV) and Research projects.
• In collaboration with pathologists, may present experimental results to senior scientific staff.
• May prepare and/or contribute to articles for publication.
• Develop relationships with teams within eDEV and broader ReDev (Research Development) to enhance collaboration and streamline processes.
• Build collaborative relationships among team members and work cooperatively with others.
• Adapt well to change, and function well with ambiguity.
• Demonstrate the ability to manage conflict.

Benefits

• Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave.
• Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 501-1,000 employees