TEMP - Scientist, Mass Spectrometry

Neurocrine Biosciences

4d

About The Position

Our dynamic team is seeking a motivated, collaborative, and experienced TEMP scientist to support biologics characterization for discovery and lead optimization teams. The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high-quality data to drive decision-making. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates.

Requirements

• BS/BA degree in scientific field and 2+ years of analytical chemistry experience; OR MS/MA degree in scientific field and some relevant industry experience OR PhD in related field
• Experience in protein analytical method development for identification and quantitation is required, including physicochemical and MS-based methods
• Good knowledge and demonstrated ability working with large molecule separation methods including reversed-phase HPLC, analytical SEC and CE-SDS
• Solid understanding of mass spectrometry operating principles, including ionization, ion transfer, gas-phase fragmentation, and mass analyzers
• Collaborative and highly motivated
• Ability to work as part of a team
• Strong computer skills and experience with Prism, Excel, Word, etc.
• Good communications, problem-solving, analytical thinking skills
• Detail oriented
• Ability to meet deadlines
• Good project management skills

Nice To Haves

• Experience on high-resolution TOF and/or orbitrap mass analyzers is a plus
• Working knowledge of protein chemistry, amino acid composition, primary structure, post-translational modifications, higher-order structure and protein-protein interactions is a plus

Responsibilities

• Develop and perform large molecule analytical and characterization assays under the supervision of senior scientists, including identity testing by intact mass and/or subunit analysis, glycan profiling, primary structure and PTM analysis by peptide mapping
• Perform data analysis, interpret results, draft report and document experiment in ELN, support stakeholders including discovery biology, protein engineering and lead optimization
• Perform routine maintenance of HPLC and MS systems, prepare mobile phases, execute calibration and cleaning procedures, coordinate regular preventative maintenance troubleshooting under the supervision of team leaders
• Execute sample preparation workflows, such as buffer exchange, immunoprecipitation, reduction and alkylation, enzymatic digestion
• Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals
• Track and document assay performance
• Provides recommendations to improve on process efficiency and research quality
• Other duties as assigned

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 1,001-5,000 employees