Scientist, LNP Formulations
Flagship Pioneering, Inc.•Cambridge, MA
12h•$100,000 - $143,000
About The Position
We are seeking an experienced Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) aimed at innovating next-generation LNP formulations. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment.
Requirements
- PhD or MS in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related field
- Strong hands-on experience with LNP formulations, including formulation development and optimization
- Demonstrated expertise in DOE methodologies and statistical experimental design
- Extensive experience with LNP screening and analytical techniques (e.g., DLS, encapsulation assays, stability studies, physicochemical characterization)
- Deep understanding of lipid-based delivery systems and formulation science principles
- Proven ability to work effectively in a team-oriented, fast-paced environment
- Strong problem-solving skills and ability to manage multiple priorities simultaneously
- Strong communication skills for presenting data and influencing technical decisions
Responsibilities
- Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations
- Lead formulation innovation efforts, including lipid selection, composition optimization, and process parameter evaluation
- Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics
- Apply strong analytical and statistical approaches to interpret complex datasets and guide formulation decisions
- Collaborate closely with cross-functional teams (biology, analytics, process development, and project management) to advance programs
- Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders
- Contribute to troubleshooting formulation challenges and continuously improve experimental workflows
- Support scale-up considerations and technology transfer as needed
Benefits
- Competitive compensation and benefits package
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
501-1,000 employees
